Preparation method of meropenem

A single technology of meropenem, which is applied in the field of preparation of carbapenem compound meropenem, can solve the problems of fast reaction speed, poor product purity, and many degradation products, and achieve the effect of reducing product degradation and improving product purity
CN102731504AInactive Publication Date: 2012-10-17CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
Publication Date
2012-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of meropenem as shown in the formula 1 and its hydrate. According to the method, a meropenem intermediate I is used as a raw material and a single solvent water is used as a reaction solvent to perform a hydrogenated deprotection reaction in the presence of alkali and a catalyst. The single solvent water is used as a reaction solvent in the method provided by the invention, thus solving the problem of dissolving the catalyst by the reaction solvent, reducing product degradation and raising product purity. In addition, the preparation method is economical, safe and environmentally friendly, and is more suitable for industrial operation at large scale.
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Description

technical field

[0001] The invention belongs to the field of synthesis of carbapenem antibiotics, in particular to an improved preparation method of carbapenem compound meropenem. Background technique

[0002] Meropenem, also known as Meropenem, Meropenem, the chemical name is 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)- 4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid, the structural formula is shown in formula 1:

[0003]

[0004] Meropenem is a second-generation carbapenem antibiotic first developed by Sumitomo Pharmaceuticals Co., Ltd. It was launched in the form of Meropenem trihydrate in January 1995 under the trade name Merrem (美平). . It is the first carbapenem antibiotic that can be used alone, and it is also the first β-methyl carbapenem antibiotic. Because meropenem introduces a methyl group at the C-1 position of the structure, this methyl group is resistant to renal dehydropeptidase-1 (DHP-1), so it does not need to...

Claims

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