Method for extracting corosolic acid from globeflower

A technology of corosolic acid and nasturtium, applied in the field of natural organic chemistry, can solve the problems of low extraction purity and low extraction rate, and achieve the effects of short extraction time, low extraction temperature and increased yield

Active Publication Date: 2012-10-17
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: a kind of method utilizing microwave extraction-macroporous resin combination technology to purify corosolic acid in nasturtium lotus, its steps are as follows:

[0016] (1) 1 kilogram of nasturtium lotus is pulverized, mixed with 50% ethanol with a concentration of 1: 6, extracted twice by microwave, the microwave power is 200W, the frequency is 4000MHz, the extraction time is 60s, and the extraction temperature is 60°C ; Filter through the plate and frame, and combine the extracts.

[0017] (2) The extract is concentrated under reduced pressure, the pressure is controlled at 0.1Mpa, the temperature is controlled at 50°C, and concentrated to no alcohol.

[0018] (3) Centrifuge the concentrated solution, and control the temperature to 30°C.

[0019] (4) The filtration residue after separation is fully dissolved in an aqueous ethanol solution with a concentration of 30% to obtain a mixed solution, filtered to obtain a filtrate, and the concentrated solutio...

Embodiment example 2

[0023] Implementation case 2: a method for purifying corosolic acid in nasturtium by utilizing microwave extraction-macroporous resin combination technology, the steps are as follows:

[0024] (1) 1 kilogram of nasturtium lotus is pulverized, mixed with the ethanol that concentration is 60%, its material-liquid ratio is 1: 8, through microwave extraction 2 times, microwave power is 400W, frequency 6000MHz, extraction time 70s, extraction temperature is 65 ℃; filter through the plate and frame, and combine the extracts.

[0025] (2) The extract is concentrated under reduced pressure, the pressure is controlled at 015Mpa, the temperature is controlled at 55°C, and concentrated to no alcohol.

[0026] (3) Centrifuge the concentrated solution, and control the temperature at 40°C.

[0027] (4) The filtration residue after separation is fully dissolved in an aqueous ethanol solution with a concentration of 30% to obtain a mixed solution, filtered to obtain a filtrate, and the conce...

Embodiment example 3

[0031] Implementation case 3: a method for purifying corosolic acid in nasturtium lotus using microwave extraction-macroporous resin combination technology, the steps are as follows:

[0032] (1) 1 kilogram of nasturtium lotus is pulverized, mixed with the ethanol that concentration is 70%, its material-liquid ratio is 1: 10, through microwave extraction 2 times, microwave power is 600W, frequency 8000MHz, extraction time 80s, extraction temperature is 70 ℃; filter through the plate and frame, and combine the extracts.

[0033] (2) The extract is concentrated under reduced pressure, the pressure is controlled at 0.2Mpa, the temperature is controlled at 60°C, and concentrated to no alcohol.

[0034] (3) Centrifuge the concentrated solution, and control the temperature at 50°C.

[0035] (4) The filtration residue after separation is fully dissolved in an aqueous ethanol solution with a concentration of 30% to obtain a mixed solution, filtered to obtain a filtrate, and the conce...

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PUM

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Abstract

The invention belongs to the field of natural organic chemistry, and relates to a method for purifying corosolic acid in globeflower by using a microwave extraction-macroporous resin combined technology. The method is characterized in that: the purpose of the method is to overcome disadvantages of relatively low extraction rate, low extraction purity and the like of the conventional technology, and to provide a method for purifying corosolic acid in globeflower by using a microwave extraction-macroporous resin combined technology. The method has the following advantages that: the microwave extraction is adopted, such that advantages of low extraction temperature, high efficiency, short extraction time, and the like are provided, the corosolic acid extraction rate is substantially improved, and the extraction time is shortened; the macroporous resin is adopted to adsorb the corosolic acid, such that the good adsorption effect on the corosolic acid is provided; and an ethanol water solution is adopted to extract corosolic acid, such that the dissolving effect is good, the corosolic acid consumption is reduced, and the yield is increased.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying corosolic acid in nasturtium by utilizing microwave extraction-macroporous resin combined technology. Background technique: [0002] Nasturtium, perennial herb, 30-70cm tall. The whole plant is hairless. Stems erect, unbranched, sparsely 2-4 leaves. Basal leaves 1-1, 16-36cm long, with long stalk, 12-30cm long stalk, narrowly sheathed at base; leaf blade pentagon, 3.8-6.8cm long, 6.8-12.5cm wide, 3-lobed, central lobes rhombic , apex acute, 3 lobes reaching the middle or slightly beyond the middle, with unequal triangular serrations on the edge; the entire lobe is oblique fan-shaped, 2 deep lobes near the base, the upper deep lobe is similar to the central full lobe, and the lower deep lobe is smaller , oblique rhombus; cauline leaves alternate, leaf shape similar to basal leaves, leaves born in the lower part of the stem with long stalks, the upp...

Claims

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Application Information

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IPC IPC(8): C07J63/00
Inventor 姚德坤姚德利张亚红万莉
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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