Detection device

Abstract

A detection device includes a flow channel for a fluid sample, a suction section adapted to draw the fluid sample into the flow channel, an optical device disposed in the flow channel, a light source adapted to irradiate the optical device with light, a light detection section adapted to detect light emitted from the optical device, a microbalance sensor chip having a piezoelectric substrate provided with an oscillation electrode, and disposed in the flow channel, and a quantitative analysis section adapted to perform quantitative analysis on the fluid sample based on output from the light detection section and the microbalance sensor chip. The optical device has a metal nanostructure including projections ranging in size from 1 through 1000 nm, and emits light representing the fluid sample adsorbed to the metal nanostructure.

Description

technical field [0001] The present invention relates to a detection device and the like for quantitatively analyzing an extremely trace substance to be qualitatively analyzed. Background technique [0002] In recent years, SERS (Surface Plasmon Resonance) using SPR (Surface Plasmon Resonance), especially SERS (Surface Plasmon Resonance) using LSPR (Localized Surface Enhanced Raman Scattering (Surface Enhanced Raman Scattering) spectroscopy (Patent Documents 1 and 2) has attracted attention. The so-called SERS is that Raman scattered light is enhanced to 10 on the metal surface with nano-scale concave-convex structure. 2 ~10 14 double phenomenon. Single-wavelength excitation light such as laser light is irradiated onto sample molecules. The spectrum detects the scattered wavelength (Raman scattered light) that deviates from the wavelength of the excitation light only by the molecular vibrational energy of the sample molecule, thereby obtaining the fingerprint spectrum of ...

AI Technical Summary

Problems solved by technology

In Patent Document 4, it is pointed out that the quantitative analysis precision of both SPR and QCM is about 1 ng / cm 2 (Paragraph 0003, 0005), and pointed out that the two quantitative analysis signals are complementary (paragraph 0102), but there is no specific explanation on how to perform quantitative analysis based on the two signals, especially how to perform quantitative analysis on extremely trace substances

Moreover, since neither the attenuated total reflection surface plasmon resonance (SPR) nor QCM can measure the fingerprint spectrum of the sample molecules that should be quantified, it is technically impossible to qualitatively detect the sample molecules.

Images