Small-volume levocarnitine freeze-dried powder injection and its preparation method and production device

A technology of freeze-dried powder injection and small volume, which is applied in freeze-dried transportation, devices for making medicines into special physical or ingestible forms, powder transportation, etc., which can solve the problems of increased filling volume, reduced output, and low product output. and other issues, to achieve the effect of reducing packaging volume, increasing output, and reducing energy consumption

Active Publication Date: 2015-10-28
REYOUNG PHARMA
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Currently commercially available levocarnitine freeze-dried powder injections are filled in 20ml vials, so the volume of the inner packaging container is large, and the area occupied by each bottle in the freeze-drying box is large, resulting in low output of each batch of products. Due to the addition of mannitol as an excipient in the formulation of levocarnitine freeze-dried powder injection, a large amount of solvent is needed to dissolve mannitol in the preparation process so as to make levocarnitine freeze-dried powder injection
The original preparation process did not control the preparation temperature, and the temperature is generally between 20°C and 25°C during concentrated preparation. Therefore, it is necessary to add 12.5 times the water of the excipient (mannitol) in the prescription to dissolve it, thereby increasing the filling volume. In order to ensure the sublimation rate of water during the freeze-drying process, 20ml vials are used for filling, resulting in a decrease in the output of each batch, increased energy consumption due to more moisture in freeze-drying, and increased packaging and transportation costs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Small-volume levocarnitine freeze-dried powder injection and its preparation method and production device
  • Small-volume levocarnitine freeze-dried powder injection and its preparation method and production device
  • Small-volume levocarnitine freeze-dried powder injection and its preparation method and production device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] The preparation method of small-volume levocarnitine freeze-dried powder injection is to lower the temperature below 50°C, add mannitol, stir and dissolve, keep the solution temperature between 30-35°C, then add levocarnitine, and keep the liquid temperature at 30°C ~35°C. After the feed liquid is dissolved, take a sample to test the pH value of the feed liquid, which is required to be controlled between 5.5 and 6.5, and add 0.1% (W / V) activated carbon for decolorization for 30 minutes.

[0025] Turn on the second Grundfos pump 9 and use the titanium rod filter 2 for decarburization and filtration, pass the feed liquid through the second sterilizing filter element 8 to sterilize, and transport it to the aseptic insulation solution storage tank 3 for storage. After sterilizing and filtering, add the remaining amount of water for injection at 30-35°C to the heat-preserving dispensing tank 1, transport it to the titanium rod filter 2 through the heat-insulating...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of freeze-dried powder injection preparation, and relates to a small-size levocarnitine freeze-dried powder injection, a preparation method and a production device thereof; the injection is characterized in that the levocarnitine freeze-dried powder injection is filled in a 15-ml tubular penicillin bottle, and the levocarnitine content in the levocarnitine freeze-dried powder injection is 1 g. Compared with the prior art, the invention has the beneficial effects of effectively increased yield, reduced energy consumption, reduced package size, and thus reduced packaging and transport cost; the filling amount is reduced to be only 6-7 ml; the freeze-drying and evaporation energy consumption is greatly reduced; and the cost is further reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of freeze-dried powder injection, and relates to a small-volume levocarnitine freeze-dried powder injection, a preparation method and a production device thereof. Background technique [0002] Currently commercially available levocarnitine freeze-dried powder injections are filled in 20ml vials, so the volume of the inner packaging container is large, and the area occupied by each bottle in the freeze-drying box is large, resulting in low output of each batch of products. Due to the addition of auxiliary material mannitol in the formulation of levocarnitine freeze-dried powder injection, a large amount of solvent is needed to dissolve mannitol in the preparation process so as to make levocarnitine freeze-dried powder injection. The original preparation process did not control the preparation temperature, and the temperature is generally between 20°C and 25°C during concentrated preparation. Th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/205A61J3/02A61P3/02
Inventor 何茂群苗得足张光明白先杰司吉晖张国明
Owner REYOUNG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products