Rotary-type micro-dynamic incubator

A dynamic culture and rotation technology, applied in the field of biotechnology or reproductive medicine, can solve the problems of complex components, incomparable embryo quality and implantation rate, complex environment for embryo development, etc., and achieve the effect of improving pregnancy rate

Inactive Publication Date: 2012-12-05
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the in-depth research of the laboratory research group, the in vitro culture system of embryos or gametes is becoming more and more perfect. Various culture conditions (gas phase, temperature) try to completely simulate the internal environment of the female reproductive system (uterus or fallopian tube), but it is different from the natural development of embryos i...

Method used

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  • Rotary-type micro-dynamic incubator
  • Rotary-type micro-dynamic incubator
  • Rotary-type micro-dynamic incubator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] figure 1 It is a rotary micro-dynamic incubator, which is composed of a box body 1, a tray 2, a motor 7, a transmission mechanism and a motor speed regulating device.

[0028] The center of the pallet is equipped with a central shaft 3, and the two ends of the central shaft of the pallet are supported by bearings.

[0029] The transmission mechanism is a belt transmission mechanism, including a large pulley 4, a small pulley 6 and a transmission belt 5, wherein the center shaft 3 is fixedly connected with the large pulley 4 (driven wheel), and the output shaft of the motor 7 is connected with the small pulley 6 (driving wheel). Wheel) is affixed, and small pulley is connected with big pulley by transmission belt 5. Tray 2 can be driven by motor 7 to rotate like this.

[0030] Motor 7 is a reduction motor.

[0031] In addition, the motor speed control device 10 is an electronic speed control device, which is connected to the motor 7 and adjusts the motor to control th...

Embodiment 2

[0039] The transmission mechanism of this embodiment adopts a gear transmission mechanism.

[0040] exist Figure 5 Among them, the gear transmission mechanism is made up of driving gear 11 (pinion) and driven gear 12 (big gear). The driving gear 11 is fixedly connected to the output shaft of the motor by bolts, and the driven gear 12 is fixedly connected to the central axis of the pallet by bolts. The motor drives the driving gear to drive the passive gear, thereby driving the tray to rotate at a lower speed.

[0041] In this embodiment, a double-layer tray is provided on a central axis. The first-layer pallet 2 is below the second-layer pallet 13 , and the double-layer pallets are respectively connected to the central shaft 3 .

[0042] In addition, the card slot is a bar-shaped groove. The bottom of the culture dish used is also provided with a bar-shaped convex line suitable for the bar-shaped groove.

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Abstract

The invention discloses a rotary-type micro-dynamic incubator which comprises an incubator box, a motor, a transmission mechanism and a motor speed-adjusting device. A tray is arranged in the incubator box and provided with a central shaft and a retaining groove for placement of an incubation dish, the central shaft is fixedly connected with the center of the tray, the retaining groove is arranged on a face of the tray, the central shaft of the tray is connected with the motor through the transmission mechanism, and the tray is driven by the motor which is connected with the motor speed-adjusting device. State of motion of oocytes or embryos in parents is simulated by slowly rotating the tray to enable the oocytes or the embryos to be in a dynamic incubation environment in in-vitro culture, so that in-vitro maturation of the oocytes or development quality of the embryos can be remarkably improved, later implantation of the embryos is promoted, and rate of pregnancy is increased.

Description

technical field [0001] The invention relates to the field of biotechnology or reproductive medicine, in particular to an incubator capable of dynamically cultivating oocytes or embryos. Background technique [0002] In animal embryo engineering research or human assisted reproductive technology, in vitro maturation of oocytes, fertilization or in vitro culture of pre-implantation embryos is a routine operation in the laboratory, mainly carried out in an incubator. [0003] To improve the in vitro development quality of gametes or embryos, laboratory research mainly focuses on the optimization of medium components, addition of cytokines, appropriate oxygen concentration, etc. With the in-depth research of the laboratory research group, the in vitro culture system of embryos or gametes is becoming more and more perfect. Various culture conditions (gas phase, temperature) try to completely simulate the internal environment of the female reproductive system (uterus or fallopian ...

Claims

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Application Information

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IPC IPC(8): C12M3/00
CPCC12M21/06C12M23/10C12M23/48C12M23/50C12M27/14C12M35/04C12M41/14C12M41/42
Inventor 随刘才许娟娟曾嵘陈莉戈一峰陈声容梁元姣姚兵
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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