The invention discloses a special water-soluble fertilizer for high-quality wheat and a preparation method of the special water-soluble fertilizer, and belongs to the technical field of agricultural fertilizers. The special water-soluble fertilizer for the high-quality wheat is prepared from the following raw materials in parts by weight: 60 to 75 parts of urea, 10 to 20 parts of monoammonium phosphate, 5 to 15 parts of potassium chloride, 1 to 10 parts of iron, 1 to 5 parts of manganese, 1 to 10 parts of boron, 5 to 15 parts of zinc, 1 to 5 parts of copper, 0.01 to 0.1 part of urease inhibitor and 0.01 to 0.1 part of nitrification inhibitor. The prepared water-soluble fertilizer has the characteristics of high dissolving speed, relatively high absorption and utilization rate, multiple nutrients and the like, can be applied to facility agriculture such as spraying, drip irrigation and the like, realizes water and fertilizer integration, improves the utilization efficiency of water andfertilizer, and achieves the effects of saving water, fertilizer and labor; meanwhile, the fertilizer can reduce the damage to soil and the environment caused by long-term use of a large amount of chemical fertilizer. In addition, the method can also be used for foliar fertilizer spraying and soilless culture.