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Medical device with slideable coating, and syringe

A technology of medical appliances and covering layers, which is applied in the field of medical appliances, can solve the problems of insoluble particles and achieve good sliding properties

Active Publication Date: 2015-06-10
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the gaskets shown in Patent Documents 4 and 5, there are many kinds of materials for forming the covering layer, which causes problems in manufacturing and cost.
In addition, in the gasket disclosed in Patent Document 6, there is a problem that solid fine particles retained in the coating layer are detached from the coating layer, and insoluble fine particles appear in the chemical solution.

Method used

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  • Medical device with slideable coating, and syringe
  • Medical device with slideable coating, and syringe
  • Medical device with slideable coating, and syringe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] (ingredient 1a)

[0098] Weigh 125g of octamethylcyclotetrasiloxane, 5g of 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane, and 2.5g of dodecane in a 300mL tall beaker Benzenesulfonic acid and 22.5 g of water were stirred with a homomixer at a rotation speed of 6,000 rpm for 10 minutes, and then 100 g of water was gradually added at a rotation speed of 2,000 rpm to perform rough emulsification. After degassing under reduced pressure, use a pressure homogenizer at a pressure of 300kg / cm 2 The emulsification was carried out twice under the conditions. The refined emulsion was reacted at 70°C for 6 hours, then kept at 15°C for 12 hours for emulsion polymerization, and the polymerization was completed by adjusting the pH to 6.0 with 10% aqueous sodium carbonate solution. The polysiloxane obtained by polymerization had a molecular weight of 330,000 and a vinyl content of 4.5 wt%. The resulting preparation was used as component 1a.

[0099] (ingredient 1b)

[0100] In a ...

Embodiment 2

[0108] (ingredient 1a)

[0109] In addition to changing 5 g of 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane in Example 1 into 10 g of 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane Except for alkane, it was carried out in the same manner as in Example 1, and the obtained preparation product was used as component 1a. Wherein, the polysiloxane obtained by polymerization has a molecular weight of 310,000 and a vinyl content of 5.4 wt%.

[0110] (ingredient 1b)

[0111] The prepared product obtained in the same manner as in Example 1 was used as component 1b.

[0112] (ingredient 2)

[0113] The prepared product obtained in the same manner as in Example 1 was used as component 2.

[0114] (ingredient 3)

[0115] As component 3, phenyltriethoxysilane, γ-ureidopropyltriethoxysilane, and γ-glycidoxypropyltrimethoxysilane were used.

[0116] (coating solution)

[0117] Mix 100 g of component 1a, 6.8 g of component 1b, 0.34 g of component 2, 1 g of phenyltriethoxysilane of c...

Embodiment 3

[0119] (ingredient 1a)

[0120] In addition to changing 5 g of 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane in Example 1 into 1 g of 1,3,5,7-tetravinyltetramethylcyclotetrasiloxane Except for alkane, it was carried out in the same manner as in Example 1, and the obtained preparation product was used as component 1a. Wherein, the polysiloxane obtained by polymerization has a molecular weight of 350,000 and a vinyl content of 3.8 wt%.

[0121] (ingredient 1b)

[0122] The prepared product obtained in the same manner as in Example 1 was used as component 1b.

[0123] (ingredient 2)

[0124] The prepared product obtained in the same manner as in Example 1 was used as component 2.

[0125] (ingredient 3)

[0126] As component 3, phenyltriethoxysilane, γ-ureidopropyltriethoxysilane, and γ-glycidoxypropyltrimethoxysilane were used.

[0127] (coating solution)

[0128] Mix 100 g of component 1a, 0.68 g of component 1b, 0.17 g of component 2, 1 g of phenyltriethoxysilane of c...

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Abstract

A medical appliance 1 having a slidable coating layer of the present invention moves in contact with an inner surface of a medical member or that of a lumen and has the slidable coating layer 3 formed at a part thereof which contacts the medical member or the lumen. The slidable coating layer 3 is formed of a composition which does not contain solid fine particles and contains a silicone-based resin which is a product of an addition reaction between silicone having a vinyl group and silicone having a hydrogen group bonded to a silicon atom.

Description

technical field [0001] The present invention relates to a medical device having a slidable coating having stable slidability, for example, to a gasket for a syringe and a syringe in which the gasket has stable slidability. Background technique [0002] Conventionally, prefilled syringes prefilled with medical solutions have been used for reasons such as taking wrong medicines, preventing nosocomial infections, disposability, and efficiency of hospital work. No matter what kind of syringe is used for the prefilled syringe, the syringe is generally composed of an outer cylinder, a spacer slidable in the syringe, and a plunger that operates the spacer to move. In most syringes, in order to improve the slidability of the gasket and obtain high flow accuracy without serious spraying when the liquid is sprayed out, silicone oil or the like is applied as a lubricant to the sliding part of the outer surface of the gasket or to the syringe. on the inner surface. However, it is know...

Claims

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Application Information

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IPC IPC(8): A61M5/315F16J15/16
CPCA61M5/31513F16J15/3284A61L29/085A61M2205/0222A61M2205/0238C09D183/14C08G77/12C08G77/20
Inventor 阿部吉彦渡边英二
Owner TERUMO KK
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