Traditional Chinese medicine composition for inhibiting vasculogenic mimicry and angiogenesis of intestinal cancer and application thereof
A vascular mimicry and composition technology, which is applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve problems such as the ratio of raw materials for undisclosed traditional Chinese medicine compounds, and achieves improved body weight in the later stage, low price, and good application prospects. Effect
Inactive Publication Date: 2014-02-19
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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However, the above-mentioned paper did not disclose the raw material ratio of the Chinese medicine compound
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Embodiment 1
[0026] Example 1 Preparation of Traditional Chinese Medicine Composition for Inhibiting Colon Cancer Vascular Mimicry and Microvascular Formation (1)
[0027] 6 parts of zedoary, 35 parts of purslane, 10 parts of mulberry fruit, 35 parts of rattan pear root, 10 parts of winter melon seeds, decocted in conventional methods.
Embodiment 2
[0028] Example 2 Preparation of Traditional Chinese Medicine Composition for Inhibiting Colon Cancer Vascular Mimicry and Microvascular Formation (2)
[0029] 12 parts of zedoary, 25 parts of purslane, 20 parts of mulberry fruit, 25 parts of rattan pear root, 20 parts of winter melon seeds, decocted in conventional methods.
Embodiment 3
[0030] Example 3 Preparation of Traditional Chinese Medicine Composition for Inhibiting Colon Cancer Vascular Mimicry and Microvascular Formation (3)
[0031] 6 parts of zedoary, 25 parts of purslane, 20 parts of mulberry fruit, 35 parts of vine pear root, 10 parts of winter melon seeds, decocted in conventional methods.
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The invention provides a traditional Chinese medicine composition for inhibiting vasculogenic mimicry and angiogenesis of intestinal cancer. The composition is prepared by the following raw materials by weight: 6 to 12 parts of rhizoma curcumae, 25 to 35 parts of herba portulacae, 10 to 20 parts of fructus fici pumilae, 25 to 35 parts of radix actinidiae chinensis and 10 to 20 parts of semen benincasae. In addition, the invention provides application of the above traditional Chinese medicine composition in preparation of medicines for treating intestinal cancer and inhibiting vasculogenic mimicry and angiogenesis of intestinal cancer. The traditional Chinese medicine composition has the advantages of being capable of inhibiting the growth of intestinal cancer, and having the effects on inhibiting vasculogenic mimicry and angiogenesis of intestinal cancer, improving the symptoms of hair color, activities, diet, diarrhea and the like of the mice, and especially improving the later stage weight of the mice, so that the effect on improvement of the survival quality of the mice suffering from the intestinal cancer is generated; furthermore, the traditional Chinese medicine composition is made from pure traditional Chinese medicines and has the advantages of being free from toxic and side effects and low in price etc., thereby being easy for patients to accept; and the quantity of the traditional Chinese medicines is little, the raw materials are abundant, the preparation technology is simple, and the medicine is harmless to the environment, so that the medicine has good application prospect on treatment of intestinal cancer.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition for inhibiting intestinal cancer vascular mimicry and microvessel formation and application thereof, in particular to a Chinese patent medicine prepared from Chinese herbal medicines. Background technique [0002] Colorectal cancer is one of the common malignant tumors, and its global incidence has ranked 2-3 among tumors. Due to the low diagnosis rate of colorectal cancer in the early stage, most of them are already in the middle and advanced stages once they are discovered, resulting in a very high mortality rate. According to the statistical report of NCHS (National Center for Health Statistics) in 2010, the mortality rate of colon cancer ranks second among all tumors, and the 5-year survival rate of advanced patients is only 8.1%. Although traditional surgery, radiotherapy and chemotherapy, and newer biological targeted therapy have certain curative effects, most bowel cancers, es...
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IPC IPC(8): A61K36/9066A61P35/00
Inventor 侯风刚
Owner SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE