Glucoside derivate
A compound and alkyl technology, applied in the field of medicine, can solve problems such as insufficient net energy
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[0129] The preparation method of the compound of the general formula (I) of the present invention comprises making the compound shown in the general formula (IV), its pharmaceutically acceptable salt, its easily hydrolyzed ester or its isomer, and the compound shown in the general formula (V) , its pharmaceutically acceptable salt, its easily hydrolyzed ester or its isomer undergoes a nucleophilic reaction,
[0130]
[0131] Among them, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 7a , R 7b , R 7c , X, n and A are as defined above.
[0132] The above-mentioned compounds of the present invention can be synthesized by the methods described in the following schemes and / or other techniques known to those of ordinary skill in the art, but are not limited to the following methods.
[0133] When X is methylene, the reaction scheme is:
[0134]
[0135]
[0136] Reaction steps:
[0137] The preparation of step 1 compound a
[0138] Dissolve raw material 1 and N-me...
Embodiment 2
[0209] Example 2 Preparation of β-1'-deoxy-1'-(4-sulfonamido-3-(p-ethoxybenzyl)benzene)-glucose acetal (compound 2) prepare
[0210]
[0211] Reference Example 1 obtained 4.35 g of the compound β-1'-deoxy-1'-(4-sulfonamido-3-(p-ethoxybenzyl)benzene)-glucose acetal with a yield of 93%.
[0212] Molecular formula: C 21 h 27 NO 8 S molecular weight: 453.15LC-MS(M+H) + :454
Embodiment 3
[0213] Example 3 β-1'-deoxy-1'-(4-sulfonylmethylamino-3-(p-ethoxybenzyl)benzene)-glucose acetal (compound 3) preparation
[0214]
[0215] Step 1 Preparation of (5-bromo-2-chlorophenyl) (4-ethoxyphenyl) ketone
[0216]
[0217] 5-Bromo-2-chlorobenzoic acid (10 g, 42.64 mmol) was dissolved in 20 mL of dichloroethane, and oxalyl chloride (5 g, 40 mmol) was added dropwise within 30 minutes, and stirring was continued for 30 minutes after completion. Then the solvent was removed by rotary evaporation as much as possible, the residue was dissolved in 30mL of dichloromethane, aluminum chloride (6.24g, 51.17mmol) was added, cooled in an ice-water bath, and ethoxybenzene (6.83g, 51.17mmol) was slowly added dropwise, After completion, stir overnight at room temperature, then pour the reaction solution into 20 mL of ice-water mixture, separate the layers, extract the aqueous phase once with dichloromethane, wash the combined organic phase with water and saturated sodium chlori...
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