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Application of oil orange to preparation of anti-H1N1 flu medicament

A technology of emblica and medicine, applied in the field of use of emblica in pharmacy, can solve problems such as no reports of anti-influenza virus, and achieve the effects of alleviating symptoms of viral pneumonia and reducing lung index

Inactive Publication Date: 2012-12-26
GUANGDONG SONGSHANHU ZHENDE BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through modern medical research, it has been found that emblica has anti-oxidation, anti-aging, fat-lowering, weight-loss, anti-cancer, hypoglycemic, anti-bacterial and anti-hepatitis B virus effects, but there is no report on anti-influenza virus of emblica and its extracts

Method used

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  • Application of oil orange to preparation of anti-H1N1 flu medicament
  • Application of oil orange to preparation of anti-H1N1 flu medicament
  • Application of oil orange to preparation of anti-H1N1 flu medicament

Examples

Experimental program
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Effect test

example 1

[0019] (I) Preparation of flavonoids extract from Amla emblica

[0020] Take 2000g of emblica medicinal material, add 10 times the amount of water to extract 3 times, filter, collect the filtrate, concentrate to 2500ml, add hydrochloric acid to adjust the pH to 3-4, and filter; the filtrate is passed through D-101 macroporous adsorption resin column, first Wash with water until the pH of the effluent is neutral, then wash the column with ethanol with a volume concentration of 70%, collect the ethanol eluate and concentrate to contain 1g of emblica crude drug in every milliliter of medicinal liquid, and the concentrated solution uses n-butanol extracting, concentrating the extracting solution to obtain, and drying to obtain powdered emblica flavonoid extract.

[0021] (Ⅱ) Determination of total flavonoids in emblica flavonoids extract

[0022] 1. Instruments and reagents

[0023] 1.1 Instrument

[0024] SPECTRONIC GENESYSTM 2 UV-visible spectrophotometer (SPECTRONIC, USA), C...

example 2

[0054] (I) Preparation of flavonoids extract from Amla emblica

[0055] Take 1500g of emblica medicinal material, add 8 times the amount of water to extract 3 times, filter, collect the filtrate, concentrate to 1500ml, add hydrochloric acid to adjust the pH to 2-3, take the acidic filtrate to pass through the macroporous adsorption resin column, the type of macroporous resin used For D-101-I, first wash with water until the effluent is neutral; then add 70% ethanol to wash the column; collect the ethanol eluate and concentrate to contain 1.2g of emblica raw material per ml of liquid; the concentrate The aqueous solution is extracted with n-butanol; the n-butanol extraction solution is concentrated to obtain the extract powder of Amla emblica.

[0056] (Ⅱ) Determination of total flavonoids in emblica flavonoids extract

[0057] Adopt the same method of example 1 to measure the flavonoid extract of the emblica flavonoids obtained by the method described in this example, and the...

example 3

[0064] (I) Preparation of flavonoids extract from Amla emblica

[0065] Take 1000g of emblica medicinal material, add 7 times the amount of water to extract twice, filter, collect the filtrate, concentrate to 835ml, add hydrochloric acid to adjust the pH to 4-5, and filter; take the acidic filtrate and pass it through a macroporous adsorption resin column. The pore resin model is AB-8, first wash with water until the effluent is neutral; then add 80% ethanol to wash the column; collect the ethanol eluate and concentrate it to contain 0.8g of emblica raw material per milliliter of liquid medicine; concentrate Extract the aqueous solution with n-butanol; concentrate the n-butanol extraction solution to obtain emblica extract powder.

[0066] (Ⅱ) Determination of total flavonoids in emblica flavonoids extract

[0067] Adopt the same method of example 1 to measure the flavonoid extract of the emblica flavonoids obtained by the method described in this example, and the total flavo...

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Abstract

The invention relates to an application of oil orange to pharmacy, in particular to an application of oil orange to preparation of an anti-H1N1 flu medicament. The anti-H1N1 flu medicament is a clinically-acceptable preparation prepared by mixing an oil orange flavone extract with the conventional dosage of medically-acceptable auxiliary materials. The medicament has a remarkable inhibiting action on an H1N1 flu virus CPE (Cytopathic Effect), and can be used for remarkably lowering the lung index of an infected person clinically and relieving the viral pneumonia symptom of the infected person.

Description

technical field [0001] The invention relates to traditional Chinese medicine single prescription emblica, in particular to the use of emblica in pharmacy. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus that is more serious than the common cold. It is characterized by acute onset, strong infectivity, high incidence and long course. At present, the most effective way to prevent and treat influenza is to inoculate influenza vaccine. However, due to the strong variability of influenza virus, the existing vaccine can be invalidated, thus increasing the difficulty of prevention and control. [0003] At present, research on anti-influenza virus drugs has achieved preliminary results, and four drugs such as ribavirin and Tamiflu have been officially launched abroad. However, the flu virus has mutated and developed resistance to these drugs to varying degrees, and most western medicines may cause serious side effects. Ho...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61P31/16
Inventor 许仕杰李耿赖小平姚海燕
Owner GUANGDONG SONGSHANHU ZHENDE BIOLOGICAL MEDICAL TECH
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