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Mailuoning ester and preparation method and function thereof

A technology of Mailuoning Ester and Mailuoning, which is applied in the field of medicine, can solve problems such as unclear active ingredients, complex ingredients of Mailuoning injection, and unreasonable quality standards, and achieve the goals of reducing MDA content, increasing SOD activity, and improving survival rate Effect

Active Publication Date: 2014-07-16
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine compound preparation Mailuoning Injection has complex components, among which unknown ingredients account for a considerable proportion, the active ingredients are not yet clear, and key scientific issues such as unreasonable quality standards are the core technical issues in the research and development of Mailuoning Injection

Method used

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  • Mailuoning ester and preparation method and function thereof
  • Mailuoning ester and preparation method and function thereof
  • Mailuoning ester and preparation method and function thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Isolation and Identification of Compound I from Mailuoning Injection

[0032] 1. Instruments and materials

[0033] Mass spectrum was measured with Packard1100MSD mass spectrometer detector (ESI-MS70V); nuclear magnetic resonance spectrum was measured with Bruker AV-300 type nuclear magnetic resonance instrument (TSM internal standard); melting point was measured with Reichert type micro melting point apparatus; Sephadex LH-20 is a product of Pharmacia Company, Normal-phase column chromatography and thin-layer chromatography silica gel are products of Qingdao Ocean Chemical Factory, reversed-phase column material is YMCAA12S50, and all reagents used are of analytical grade. The HPLC analysis column is Nova-PakC18 column (3.9×150mm, particle size 5μm, Waters Company), and the reagents used in HPLC are chromatographically pure;

[0034] 2. Drugs

[0035] Mailuoning injection was provided by Jinling Pharmaceutical Co., Ltd. (batch number: 20110467, Ministry-is...

Embodiment 2

[0053] The new compound Ⅰ Mailuoning ester provided by the present invention can reduce the content of LDH in myocardial ischemia model rats, reduce the content of MDA, increase the activity of SOD, regulate the expression of iNOS and the synthesis of NO in myocardial cells, and obviously increase the content of H 2 o 2 and the survival rate of hypoxia / reoxygenation injured cardiomyocytes, and has a protective effect on cardiomyocytes. Its pharmacological experiment result is as follows:

[0054] (1) Purpose of the experiment

[0055] H 2 o 2 1. Hypoxia-reoxygenation stimulated H9C2 rat cardiomyocytes to prepare an in vitro anti-myocardial ischemia model. By measuring relevant indicators, the anti-oxidation effect and protective effect of malonin ester on hypoxia-reoxygenation injury were investigated, and its anti-myocardial ischemia was comprehensively evaluated. ischemic activity

[0056] (2) Experimental method

[0057] H9C2 rat cardiomyocyte model was used, and H 2...

Embodiment 3

[0106] Embodiment 3 preparation example

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Abstract

The invention belongs to the medicine field, and discloses Mailuoning ester and a preparation method and use thereof. The chemistry name of the Mailuoning ester is (E)-(5-formylfuran-2-yl) methyl-3-(3, 4-dihydroxyphenyl) acrylate. The Mailuoning ester has a protection function for cardiac muscle cells, and can be used for preparing medicine curing cardiovascular diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to mailuoning ester and its preparation method and application. The chemical name of the Mailuoning ester is (E)-(5-formylfuran-2-yl)-methyl-3-(3,4-dihydroxyphenyl)-acrylate, which is an ester extracted and separated from Mailuoning Injection new compounds. Background technique [0002] Cardiovascular system diseases are a serious threat to people's life and health, and have become the number one killer of death clinically. Countries all over the world attach great importance to the research and development of cardiovascular prevention and treatment drugs. Mailuoning Injection, a compound preparation of traditional Chinese medicine, was developed on the basis of the clinical application of the famous medical prescription "Simiao Yong'an Decoction". It has independent intellectual property rights and was officially approved for production in 1985. Dendrobium, Scrophulariaceae, Achyranthes bid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/46A61K31/341A61P9/00A61P9/10
Inventor 冯煦汤卫国王奇志徐向阳王鸣蔡莹陈雨赵友谊张蕙印敏
Owner JINLING PHARMA