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Easily dosable solid preparation

一种增粘剂、组合物的技术，应用在非有效成分的医用配制品、含有效成分的医用配制品、抗病毒剂等方向，能够解决不能指望口腔凝聚感等问题，达到良好吞咽性、溶出性改善、滑动性良好的效果

Inactive Publication Date: 2013-01-02
MOCHIDA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the coated tablet is formed into small pieces, it cannot be expected to feel cohesive in the oral cavity.

Method used

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  • Easily dosable solid preparation
  • Easily dosable solid preparation
  • Easily dosable solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～2

[0267] After mixing concentrated glycerin and ethanol, hydroxypropyl cellulose (HPC-L, showing a viscosity of 6 to 10 mPa·s, Nippon Soda Co., Ltd.) was added and dissolved. Add hydroxypropylmethylcellulose (HPMC (TC-5E), showing a viscosity of 3 mPa s, Shin-Etsu Chemical Industry Co., Ltd.) and carbopol (Carbopol 971P, showing a viscosity of 6420 mPa s, Lubrizol Advanced Material Inc.) and spread it evenly. In addition, erythritol (Mitsubishi Corporation Foodtech Co., Ltd.) and xanthan gum (Keltrol CG-T, showing a viscosity of 1555 mPa·s, Sanjing Co., Ltd.) were subjected to a jet mill (Seishin Corporation (セイシン Corporation) SJ-3) After crushing, add sequentially and make it uniformly dispersed. Finally, a solution obtained by dissolving calcium chloride dihydrate in ethanol was added, and uniformly dispersed to prepare a coating solution. Using a coating device (Powrex Dria Coater (パウレックドリアーター) 200), the above-mentioned uncoated tablet A was spray-coated (about 10% by mass ...

Embodiment 3

[0270] Except that HPC-L was not added in the coating solution preparation method of Example 1, the coated small tablets were obtained according to the preparation method of Example 1.

Embodiment 4

[0272] Except that Carbopol 974P (viscosity shown as 32850mPa·s, Lubrizol Advance Material Inc.) was used instead of Carbopol 971P in the coating liquid preparation method of Example 2, the coating was obtained according to the preparation method of Example 1 small pieces.

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Abstract

The object is to provide a preparation for oral administration having improved dosability, and / or a coating composition to be used in an easily dosable preparation, the coating composition not affecting elution properties. The object can be achieved by using a coating composition comprising a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate, a polyvalent metal compound, and a second thickener comprising at least one member selected from the group consisting of xanthan gum, guar gum and sodium alginate (provided that when the first thickener is sodium alginate, the second thickener is not sodium alginate), or a coating composition which comprises hydroxypropylmethylcellulose as a thickener and contains a sugar or sugar alcohol having a solubility at 20oC of 30 or greater.

Description

technical field [0001] The present invention relates to an easy-to-administer oral preparation with improved administration and / or a coating composition for an easily-administered preparation with improved dissolution. Background technique [0002] Currently, in pharmaceuticals, oral preparations account for a high proportion and among them, solid preparations are the mainstream. Among them, there are preparations with a large amount of dosage, and these preparations become larger when made into a single unit tablet, and when they are made into powders and granules When dosed, it will become a bulky preparation due to its low density, which makes it difficult for children and the elderly with poor swallowing function to take it in many cases. [0003] Although the orally disintegrating tablet technology has been developed for the purpose of improving tablet dosability, the content of the main drug accounts for a small amount of the entire tablet, so it is not suitable for pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/30A61K47/02A61K47/10A61K47/26A61K47/36A61K47/38
CPCA61K9/2886A61K31/00A61K9/2072A61K9/2813A61K9/284A61K9/286A61K31/522A61K31/5383A61P31/04A61P31/12A61K9/0053A61K9/2826A61K9/2866
Inventor 工藤弓夫蕨野训臣
Owner MOCHIDA PHARM CO LTD
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