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Melt-extruded film

A technology of melt extrusion and extruder, which is applied in the field of melt extrusion film and its preparation, and can solve unsolved problems such as rapid release of active ingredients

Inactive Publication Date: 2013-01-23
DOW GLOBAL TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drying method taught can be used to obtain a uniform film, US2005 / 037055 does not address the problem of how to quickly dissolve a thick film to achieve a fast release of the active ingredient contained in the film

Method used

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  • Melt-extruded film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Component A is POLYOX WSR N-80NF (trademark of Dow Chemical Company). The substance is a polyethylene oxide polymer with a molecular weight of 200,000 g / mol. Component B is ibuprofen (Spectrum Chemical). Component C is Mannitol (SPI Polyols Inc.). These materials were blended at a ratio of 55 / 25 / 20 (POLYOX WSR N-80NF / Ibuprofen / Mannitol) for 10 minutes using a laboratory V-blender.

[0042] Film extrusion was performed using a Davis standard extruder equipped with a general purpose screw of 1.25 inch diameter (32 mm) and 24 / 1 length / diameter ratio. The extruder was equipped with an 8 inch (203 mm) wide cast film die with a die gap of about 0.025 inch (0.64 mm). The extruded film was pulled from the die using a vertical 3 roll stack and cooled. Steel casting rolls were controlled at 14.5°C using a Mokon Compu-Mate 100 controller. Extruder set points are: Barrel Zone 1 = 70°C, Barrel Zone 2 = 140°C, Barrel Zone 3 = 150°C, Die Zone 1 = 150°C, Die Zone 2 = 150 °C. The...

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Abstract

A mono-layer or multi-layer film wherein at least one of the layers has a thickness of at least 0.125 mm is produced from a melt-extruded polymer composition comprising a) a water-soluble polymer, b) an active ingredient and c) an adjuvant selected from the group consisting of mono- and disaccharides, sugar alcohols, low molecular weight water soluble polymers, and salts of cross-linked carboxymethylcellulose, with the proviso that the adjuvant c) is different from the water-soluble polymer a).

Description

technical field [0001] The present invention relates to melt extruded films and methods for their preparation. Background technique [0002] Active ingredients, such as drugs or pharmaceuticals, can be prepared in tablet form to allow precise and consistent dosage. However, this form of preparation and dispensing of the drug has a number of disadvantages, including the necessity to add large proportions of excipients to obtain a manageable size, the need for additional storage space for larger drug forms, and the dispensing including a tendency towards wrong tablet counts. Also, many people have difficulty swallowing tablets. While it is possible to separate the tablet into smaller pieces or even crush it in a way that overcomes swallowing difficulties, this is not an adequate solution for many tablet or pill forms. For example, crushing or disrupting tablet or pill forms to facilitate ingestion alone or in admixture with food may also destroy the controlled-release proper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18A61K9/70C08L1/26C08L71/02B29C48/30
CPCC08J5/18C08J2301/26C08J2371/02A61K9/0056A61K31/192C08J2305/00
Inventor M.哈尔M.里德U.施雷萨
Owner DOW GLOBAL TECH LLC
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