Medicament composition for treating pulmonary interstitial fibrosis as well as preparation method and applications thereof

A technology for pulmonary interstitial fibrosis and a composition is applied in the field of pharmaceutical compositions for the treatment of pulmonary interstitial fibrosis, which can solve the problems of intractability, lack of Chinese medicine research materials, etc., and achieve the effect of remarkable effect and good clinical application prospect.

Active Publication Date: 2013-12-04
江西中医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But we are also soberly aware that there are few research materials related to TCM related to this disease, and some are case reports, which are difficult to be convincing.
In addition, most scholars base their arguments on blood stasis or deficiency of Qi and Yin, which has certain limitations in clinical practice.

Method used

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  • Medicament composition for treating pulmonary interstitial fibrosis as well as preparation method and applications thereof
  • Medicament composition for treating pulmonary interstitial fibrosis as well as preparation method and applications thereof
  • Medicament composition for treating pulmonary interstitial fibrosis as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] At room temperature, take 10 kg each of Euonymus, Rhodiola rosea, Shuidaolian, Epimedium, and Zhilicorice (50 kg in total), soak and extract with 500 kg of ethanol with a volume concentration of 95%, and the soaking time is 24 Hours, the ethanol was recovered under reduced pressure to obtain the extract, and the extract was dried in an oven at 100°C for 5 hours to obtain the ethanol extract;

[0044] The ethanol-extracted euonymus, rhodiola rosea, yellow-flowered lotus, epimedium, and licorice were refluxed with 500 kg of water to extract for 2 hours, and the specific gravity of the extract was 1.05-1.10 when concentrated to 25°C, and dried. water extract;

[0045] The pharmaceutical composition for treating pulmonary interstitial fibrosis is obtained by mixing ethanol extracts and water extracts of euonymus, rhodiola rosea, chrysanthemum, epimedium and licorice.

[0046] 100 grams of the obtained pharmaceutical composition for treating pulmonary interstitial fibrosis ...

Embodiment 2

[0048] At room temperature, take 12 kg of euonymus, 6 kg of Rhodiola rosea, 6 kg of Shuidaolian, 8 kg of epimedium, and 14 kg of roasted licorice (46 kg in total), and soak them in 460 kg of methanol with a volume concentration of 70%. Extraction, the soaking time is 24 hours, the methanol is recovered under reduced pressure to obtain the extract, and the extract is dried in an oven at 100°C for 5 hours to obtain the methanol extract;

[0049] The methanol-extracted euonymus, Rhodiola rosea, Shuidaolian, epimedium, and licorice were extracted with 460 kg of reflux for 4 hours. When the extract was concentrated to 25°C, the specific gravity was 1.05-1.10, and dried to obtain water extract;

[0050] The pharmaceutical composition for treating pulmonary interstitial fibrosis is obtained by mixing methanol extracts and water extracts of euonymus, rhodiola rosea, Shuidaolian, epimedium and licorice.

[0051] Mix 100 grams of the obtained pharmaceutical composition for treating pul...

Embodiment 3

[0053] At room temperature, take 6 kg of euonymus, 6 kg of Rhodiola rosea, 6 kg of Huanghua Shuidaolian, 10 kg of epimedium, and 18 kg of roasted licorice (46 kg in total), soak and extract with 460 kg of ethyl acetate. For 24 hours, the ethyl acetate was recovered under reduced pressure to obtain the extract, and the extract was dried in an oven at 100°C for 5 hours to obtain the ethyl acetate extract;

[0054] The euonymus, rhodiola rosea, chrysanthemum chrysanthemum, epimedium, and licorice extracted through ethyl acetate were refluxed and extracted 3 times with 460 kg of water, and the specific gravity of the extract was 1.05-1.10 when concentrated to 25°C. Dry to obtain water extract;

[0055] The medicinal composition for treating pulmonary interstitial fibrosis is obtained by mixing ethyl acetate extracts and water extracts of euonymus, rhodiola rosea, water lotus, epimedium and licorice.

[0056] Mix 100 grams of the obtained pharmaceutical composition for treating pu...

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Abstract

The invention discloses a medicament composition for treating pulmonary interstitial fibrosis as well as a preparation method and applications thereof, wherein the medicament composition for treating pulmonary interstitial fibrosis is prepared from the raw materials of winged euonymus, rhodiola rosea, polygala fallax hemsl, herba epimedii and honey-fried licorice root, and the percentage by weight of any component does not exceed 30% of the total weight. The medicament composition for treating pulmonary interstitial fibrosis as well as the preparation method and applications thereof provided by the invention breaks through the research and development convention, and are not limited to the traditional theory of traditional Chinese medicine; the pathogenesis of pulmonary interstitial fibrosis patient is intermingled with deficiency and excess; the root is deficiency of yang and congealing cold, and the symptom is stagnant phlegm and blood stasis; prescriptions are screened bravely and are combined; and the animal experiment and clinical experiment show that the medicament composition has the characteristic of obvious effect, and has favorable clinical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pulmonary interstitial fibrosis. Background technique [0002] Interstitial lung disease is a general term for many acute and chronic lung diseases with different degrees of lung inflammation and fibrosis, and pulmonary fibrosis is its final pathological outcome. Idiopathic pulmonary fibrosis (IPF) is one of the most representative types. It is a fatal diffuse pulmonary interstitial disease with unknown etiology, unclear pathogenesis, and lack of treatment. Its pathological feature is alveolar Epithelial injury and fibroblast proliferation, and the formation of fibroblast foci. In the past, glucocorticoids and cytotoxic drugs were mainly used in the treatment of IPF, but the effect was minimal. The average survival period after diagnosis of IPF was 2 to 4 years, and the 5-year survival rate was 30% to 50%. (Idiopathic Pulmonary Fibrosis Clinical Research Network.A controlled trial of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/69A61P11/00
Inventor 刘良徛张元兵兰智慧付向春
Owner 江西中医学院附属医院
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