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Poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer and preparation method thereof

A technology of isopropylacrylamide and acrylic acid, applied in the polymer field, can solve the problems of complex synthesis method and long synthesis route, and achieve the effects of broad application prospects, complete phase transformation and widening application range.

Active Publication Date: 2013-02-13
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this material has the problems of long synthetic route and complicated synthetic method.

Method used

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  • Poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer and preparation method thereof
  • Poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer and preparation method thereof
  • Poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer and preparation method thereof

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preparation example Construction

[0041] The present invention also provides a preparation method of poly(N-isopropylacrylamide)-poly(acrylic acid or acrylic acid derivative) copolymer, comprising the following steps:

[0042] Under the action of azobisisobutyronitrile, react N-isopropylacrylamide with the compound represented by formula (III) in an organic solvent at 60°C~90°C to obtain poly(N-isopropylacrylamide amide)-poly(acrylic acid or acrylic acid derivative) copolymer;

[0043]

[0044] Among them, R 1 is hydrogen or C1~C5 alkyl; R 2 It is hydrogen or C1~C5 alkyl.

[0045] The present invention reacts N-isopropylacrylamide and the compound represented by formula (III) under the action of azobisisobutyronitrile in an organic solvent at 60°C to 90°C to obtain poly(N-isopropylacrylamide) acrylamide)-poly(acrylic acid or acrylic acid derivative) copolymer.

[0046] The present invention uses N-isopropylacrylamide and the compound represented by formula (III) as raw materials to react, and the random...

Embodiment 1

[0057] Dissolve 0.9g of N-isopropylacrylamide, 0.1g of 2-butenoic acid and 0.0164g of azobisisobutyronitrile in 10mL of dimethyl sulfoxide. After dissolution, the solution is heated to 70°C for reaction, and the temperature is maintained for 24 hours to obtain crude product;

[0058] The obtained crude product was placed in a dialysis bag with a molecular weight cut-off of 7000, dialyzed in water for 72 hours, and changed the water once every 12 hours to obtain the dialysis product;

[0059] The resulting dialysis product was frozen and then freeze-dried to obtain poly(N-isopropylacrylamide)-poly(2-butenoic acid) copolymer (PNM), with an average molecular weight of 10,000.

[0060] The resulting copolymer was subjected to nuclear magnetic resonance analysis, using deuterated chloroform as a solvent. Analysis results such as figure 1 with figure 2 as shown, figure 1 The H NMR spectra of the copolymers and poly(N-isopropylacrylamide) homopolymers provided in Examples 1, 3, ...

Embodiment 2

[0063] Dissolve 0.9g of N-isopropylacrylamide, 0.1g of acrylic acid and 0.0164g of azobisisobutyronitrile in 10mL of dimethyl sulfoxide. After dissolution, the solution is heated to 70°C for reaction, and the temperature is maintained for 24 hours to obtain a crude product;

[0064] The obtained crude product was placed in a dialysis bag with a molecular weight cut-off of 7000, dialyzed in water for 72 hours, and changed the water once every 12 hours to obtain the dialysis product;

[0065] The resulting dialysis product was frozen and then freeze-dried to obtain poly(N-isopropylacrylamide)-polyacrylic acid copolymer (PNA), with an average molecular weight of 10,000.

[0066] Gained copolymer is carried out nuclear magnetic resonance analysis, with deuterated chloroform as solvent, analysis result is as follows figure 2 shown. The analysis results showed that the obtained copolymer PNA includes the first repeating unit having the structure of formula (I) and the second repea...

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Abstract

The invention provides a poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer and a preparation method thereof. The preparation method includes enabling N-isopropyl acrylamide and a compound shown as a formula (III) to react in organic solvent under the temperature of 60 DEG C to 90 DEG C under the effect of azodiisobutyronitrile to obtain the poly (N- isopropyl acrylamide)- poly (crylic acid or acrylic acid derivative) copolymer which comprises a first repeated unit with the structure of a formula (I) and a second repeated unit with the structure of a formula (II), wherein R1 is hydrogen or alkyl of C1-C5, R2 is hydrogen or alkyl of C1-C5, and the mass ratio of the first repeated unit and the second repeated unit is (70-95): (30-5). The copolymer is a random copolymer. The copolymer has good sensitivity on temperature and pH, and the preparation method is simple and easy to carry.

Description

technical field [0001] The invention relates to the technical field of polymers, in particular to a poly(N-isopropylacrylamide)-poly(acrylic acid or acrylic acid derivative) copolymer and a preparation method thereof. Background technique [0002] Intelligent polymer is a kind of material that can make a rapid physical or chemical response when the external environment such as temperature, ionic strength, pH value, electromagnetic field, etc. change, that is, its physical or chemical properties such as color, structure, or hydrophilicity change. class of polymers. Due to the unique responsiveness of smart polymers to environmental stimuli, they have broad application prospects in the field of biomedical materials. Among them, pH-sensitive or temperature-sensitive polymer materials are closely related to human physiological conditions, such as pH-responsive or temperature-responsive nano-drugs that can control the release of carriers, etc. Therefore, in practical application...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F220/06C08F220/04A61K47/32
Inventor 贺超良髙晓晔庄秀丽陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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