System for improved hemodynamic detection of circulatory anomalies

A delivery system, actuation technology for applications, medical science, diagnostic recording/measurement, etc.

Inactive Publication Date: 2013-02-13
CARDOX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is also a large number of unexplored, highly sensitive, quantifiable, low-cost methods for assessing the effectiveness and durability of closure at 3 to 4 time points for percutaneous closure of right-to-left shunts. Satisfied needs

Method used

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  • System for improved hemodynamic detection of circulatory anomalies
  • System for improved hemodynamic detection of circulatory anomalies
  • System for improved hemodynamic detection of circulatory anomalies

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0179] Example 1: Indicator Quantitative Test

[0180] The objectives of the indicator quantification test and the comparative analysis test included optimizing the injection protocol and the timing of the provocative respiratory maneuver to further improve the sensitivity of the system for the detection of right-to-left cardiac shunts. Another purpose is to determine the parameters of the test program to be used in subsequent trials. Other purposes include providing additional data for use in the development of the disclosed method for calculating and displaying the functional flow opening of a patient's right-to-left heart shunt, the "Shunt Opening Index."

[0181] Available in a single use surgical tray similar to the Figure 33 public suite. The kit contents included a vial of 25 mg of indigo green (ICG) dye (Pulsion Medical Systems, Munich) in powder form of ICG. The second bottle provides the solvent used to prepare the ICG dye solution at the desired concentration. ...

example 2

[0224] Example 2: Comparative Analysis of Dye Dilution Detection System and Existing Transcranial Doppler Detection.

[0225] A total of 17 patients between the ages of 18 and 65 with a known right-to-left shunt (i.e., PFO) and 7 without a right-to-left shunt, according to echocardiographic techniques, were diagnosed within less than 30 minutes. During the same time period, using transcranial Doppler (TCD) method and by similar Figure 47 The system shown in was tested. A cohort of 10 informed patients with known right-to-left shunts (RTLS) was included. For this study, RTLS was graded by TCD as 4 (101-300 microbubbles detected) or 5 (>300 microbubbles detected or not countable) on the Spencer scale. A control group of 7 informed patients without RTLS, ie RTLS graded by TCD as 0 (no microbubbles detected) or 1 (1–10 microbubbles detected) on the Spencer scale, was also included. Patients were studied using the ICG dose and injection schedule established in Example 1 describ...

example 3

[0277] Example 3: Calculation of shunt opening index

[0278] To calculate the shunt opening index, the sequence of calculation steps is described below. For a detector system with 6 sensor pairs, there are 6 ICG fluorescence level measurements made corresponding to the 6 laser diode / photodetector pairs arranged in the two fluorescence sensor array units, which means that the Many steps are performed on each of the six channels, and subsequent data processing is channel-specific. For example, peak and baseline values ​​are specific to each channel of the data being processed and are not averaged across the 6 channels. Therefore, the ratio of shunt curve peak to normal curve peak is channel specific, ie a known ratio value is calculated for all 6 data channels. The specific calculation steps are as follows, where the subscript i refers to the channel number between 1 and 6, and the subscript j refers to the elapsed time, elapsed(j), where all time steps have a duration of 0.0...

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Abstract

The invention generally relates to a system, and apparatus for detection of circulatory anomalies in the mammalian body. Particularly, apparatus is provided that allows the clinician to quantitatively determine the extent of any anomalies in the pulmonary circulation. Specifically a quantifiable agent is injected into a peripheral location, and the transit of the indicator agent is monitored. Aberrant circulation is then quantified. The preferred indicator is an injection of indocyanine green dye, detected and measured by fluorescence at a sensor location. Sensor arrays are provided that allow for optimization of detection of circulatory anomalies Quantification is carried out by a monitor / controller providing visual cues to the patient and operator, said monitor / controller actuable for carrying out a Valsalva maneuver, and a displaying shunt conductance index.

Description

[0001] cross reference [0002] This application is pending U.S. Patent Application Serial No. 12 / 754,888, filed April 6, 2010, entitled "Hemodynamic Detection of Circulatory System Malformations," and filed April 6, 2009, entitled "Circulatory System Hemodynamic Detection of Malformations," a continuation-in-part of U.S. Patent Application Serial No. 12 / 418,866, the disclosures of U.S. Patent Application Serial No. 12 / 754,888 and U.S. Patent Application Serial No. 12 / 418,866 are incorporated by reference way incorporated into this article. [0003] Statement on state-funded research [0004] Not applied technical field [0005] The present invention generally relates to systems, methods and devices for detecting circulatory malformations in mammalian bodies. An important type of this malformation involves the heart and includes what is commonly known as a right-to-left shunt of the heart. Background technique [0006] A common malformation in humans is the opening betwe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/02
CPCA61B8/481A61B5/0275
Inventor P.E.埃格斯A.R.埃格斯E.A.埃格斯M.A.迈耶切克
Owner CARDOX
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