Low energy propolis hard capsule preparation method

Abstract

The present invention relates to a low energy propolis hard capsule preparation method, which is characterized by comprising: mixing refined propolis and a sugar alcohol substance, carrying out steps of drying, crushing and granulating to prepare low energy propolis particles, and filling the particles into a hollow capsule to prepare the low energy propolis hard capsule. According to the present invention, a low energy value sugar alcohol substance is adopted as a carrier, steps of mixing, drying, crushing and granulating are performed to load the refined propolis on the carrier so as to prepare propolis particles with good fluidity, the propolis particles are filled into hollow capsules to prepare the low energy propolis hard capsules; compared with the conventional propolis soft capsule adopting oil as a carrier, the propolis hard capsule of the present invention has a substantially reduced energy value; and compared with the conventional propolis hard capsule adopting sucrose powder or maltodextrin as a carrier, the propolis hard capsule of the present invention does not affect glucose metabolism of patients, such that the product of the present invention is more suitable for patients with cardiovascular diseases or diabetes.

Description

technical field [0001] The invention relates to a preparation method of low-energy propolis hard capsules, belonging to the technical field of hard capsule processing. Background technique [0002] Propolis is a kind of substance that is formed by honeybee worker bees after mixing the resinous substance secreted by young shoots and callus of poplar, willow, pine and other plants with the secretions of their own digestive glands and wax glands. A viscous natural mixture; bees use propolis to protect the bee colony and fight against pests and diseases; fill the gaps in the hive, wrap and seal the corpses of invading enemies that cannot be removed from the hive, so as to prevent their corruption in the hive; propolis is very precious Biological resources, a colony of 50,000 to 60,000 bees can only produce 100-150 grams of propolis a year, so it is known as "purple gold"; [0003] Propolis is an opaque solid with a smooth or rough surface. The broken surface is sandy and the cu...

AI Technical Summary

Problems solved by technology

The soft capsule has elasticity and plasticity, which can prevent oxidation, moisture and light, and can improve the stability of the drug; because it does not contain adhesives, the material is not under pressure during the preparation process, so the drug is released quickly and has good bioavailability; content Good uniformity and low content deviation; but soft capsules usually use oily substances, such as soybean oil, rapeseed oil or olive oil, as drug carriers, so propolis soft capsules on the market are often Oily raw materials are used as the carrier. Because of the high calorie content of such substances, the propolis products on the market are also high in calories. For diabetics, especially those with cardiovascular disease, the high fat content limits the application of propolis;

[0018] Hard capsule refers to a certain amount of medicinal material extract plus medicinal powder or auxiliary materials to make uniform powder or granules, which are filled in hollow capsules, or made by directly subpackaging medicinal powder into hollow capsules; in the production of modern Chinese medicine preparations Among them, hard capsules have been widely used in recent years because of their relatively simple process, convenient administration, quick onset of action, and ability to effectively isolate the bad smell of drugs; however, conventional hard capsules usually use sucrose powder, paste, etc. Concentrated powder, etc. are used as carriers or fillers, and are not suitable for diabetics to take in large quantities;