Method for preparing phenylacetate by using ionic liquid

A technology of phenyl acetate and ionic liquid, which is applied in the field of organic chemical synthesis, can solve the problems of complex post-treatment, difficult recycling of catalysts, and low yield, and achieve the effects of good thermal stability, easy operation, and simple reaction process

Inactive Publication Date: 2013-02-27
HIGH & NEW TECH RES CENT OF HENAN ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of low yield, complex post-treatment, and difficult recycling of catalysts in the preparation of phenyl acetate in the prior art, the purpose of the present invention is to provide a new green method for preparing phenyl acetate

Method used

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  • Method for preparing phenylacetate by using ionic liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 0.3 moles of phenol, 0.1 moles of acetic anhydride and 0.1 moles of [Pr 3 NH]HSO 4

[0017] Ionic liquid, stirred and reacted at 60°C for 8 hours. After the reaction was completed, water was added, and the product phenyl acetate was isolated, and the yield of the reaction was 93%; the water-soluble ionic liquid was used for the next experiment after dehydration.

Embodiment 2

[0019] Put 0.2 mole of phenol, 0.5 mole of acetic anhydride and 0.2 mole of [NMPH]HSO into the reaction vessel 4 Ionic liquid, stirred and reacted at 80°C for 10 hours. After the reaction was completed, water was added, and the product phenyl acetate was isolated, with a reaction yield of 89%; the water-soluble ionic liquid was used for the next experiment after dehydration.

Embodiment 3

[0021] 1.5 moles of phenol, 0.5 moles of acetic anhydride and 0.3 moles of [Me 2 NH]HSO 4

[0022] Ionic liquid, stirred and reacted at 90°C for 6 hours. After the reaction was completed, water was added, and the product phenyl acetate was isolated, and the yield of the reaction was 83%; the water-soluble ionic liquid was used for the next experiment after dehydration.

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Abstract

The invention discloses a method for preparing phenylacetate by using an ionic liquid and belongs to the field of organic chemical synthesis. According to the method, phenylacetate is prepared by taking phenol and acetic anhydride as starting raw materials and using the ionic liquid which is good in thermal stability, difficult to volatilize and recyclable as a catalyst and a solvent. In the method, no any other poisonous and harmful catalysts and volatile organic solvents are used, reaction condition is moderate, synthesis process is simple, requirement for equipment is low and yield is high. The method disclosed by the invention is an environment-friendly efficient new method for synthetizing phenylacetate.

Description

technical field [0001] The invention relates to a method for preparing phenyl acetate, in particular to a method for preparing phenyl acetate by using an ionic liquid, and belongs to the field of organic chemical synthesis. Background technique [0002] Phenyl acetate is an important pharmaceutical intermediate, which can be transformed into a mixture of o-hydroxyacetophenone and p-hydroxyacetophenone, which can treat jaundice hepatitis, cholecystitis and other diseases. [0003] At present, there are three methods for synthesizing phenyl acetate: (1) phenol and acetic anhydride are synthesized under the catalysis of alkali or acid. This method has disadvantages such as long process flow, many wastes, serious pollution, and difficult recycling of catalysts; (2) Phenol and acetyl chloride are reacted to synthesize phenyl acetate. The raw material acetyl chloride used in this method is a high-risk chemical, flammable, explosive, and expensive. The reaction by-product hydrogen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/157C07C67/08
CPCY02P20/584
Inventor 郭辉张国宝庄玉伟曹健赵根锁
Owner HIGH & NEW TECH RES CENT OF HENAN ACAD OF SCI
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