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Application of curcumin solid lipid nano-particle serving as medicament for treating asthma

A technology of solid lipid nano and curcumin, which is applied in drug combination, liposome delivery, respiratory diseases, etc., can solve the problems that have not been reported, and achieve simple technical operation, stable reaction system, and improved bioavailability Effect

Inactive Publication Date: 2013-03-06
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drug-loading systems suitable for curcumin that have been studied at home and abroad, including microspheres, polymers, liposomes, solid lipid nanoparticles (SLN), etc., and the literature in this area is often used for tumor treatment and The research on overcoming the resistance of other tumor drugs, or how to improve the stability and bioavailability of curcumin, but the research on the treatment and control of asthma has not been reported at home and abroad

Method used

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  • Application of curcumin solid lipid nano-particle serving as medicament for treating asthma
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  • Application of curcumin solid lipid nano-particle serving as medicament for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 40 mg of stearic acid, 20 mg of lecithin, and 40 mg of curcumin, dissolve in 10 ml of chloroform;

[0042] Use a 10# needle to inject the organic phase into 30ml of the water phase that has been preheated to 75°C containing 30mg Myrj53 at a constant speed, and stir at 1200rpm for about 1 hour. Ionized water, continue to stir at 1200rpm at room temperature for 2 hours, fully centrifuge to collect samples, wash twice with PBS, and freeze-dry to obtain the finished drug.

[0043] The particle size of SLN-curcumin is 50-200nm, which is circular (such as figure 1 ), the surface is negatively charged, and the surface potential is -20mV (such as figure 2 ). Show that SLN-curcumin has all characteristic peaks of SLN by XRD analysis, has the part characteristic peak of curcumin simultaneously, shows that SLN wraps curcumin in lipid, and the two are organically combined (such as image 3 ).

[0044] The drug release experiment of SLN-curcumin was carried out in vitro b...

Embodiment 2

[0047] Weigh 40 mg of stearic acid, 20 mg of lecithin, and 20 mg of curcumin, and dissolve them in 10 ml of chloroform; inject the organic phase into 30 ml of the aqueous phase containing 30 mg of Myrj53 at a constant speed with a 10# needle, stir at 75 °C and 1200 rpm for about 1 hour, and wait until the system About 5ml remained, removed the water bath, quickly poured in the prepared 4°C deionized water, continued to stir at 1200rpm at room temperature for 2 hours, centrifuged fully to collect the sample, washed twice with PBS, and freeze-dried to obtain the finished drug.

[0048] The particle size of SLN-curcumin is 50-200nm, round in shape, negatively charged on the surface, and the surface potential is -25mV. In the PBS solution of 1% Tween80, the drug release of SLN-curcumin can reach more than 7 days, and the drug release can reach 45% in about 2 days.

[0049] In the blood drug concentration experiment, a total of 3 groups of BALB / C mice were used, 3 in each group, wh...

Embodiment 3

[0052] Weigh 20 mg of stearic acid, 10 mg of lecithin, and 15 mg of curcumin, and dissolve them in 10 ml of chloroform; inject the organic phase into 30 ml of the aqueous phase containing 20 mg of Myrj53 at a constant speed with a 10# needle, stir at 75 °C and 1200 rpm for about 2 hours, and wait until the system About 5ml remained, removed the water bath, quickly poured in the prepared 4°C deionized water, continued to stir at 1200rpm at room temperature for 2 hours, centrifuged fully to collect the sample, washed twice with PBS, and freeze-dried to obtain the finished drug.

[0053] The particle size of SLN-curcumin is 50-200nm, round in shape, negatively charged on the surface, and the surface potential is -25mV. In the PBS solution of 1% Tween80, the drug release of SLN-curcumin can reach more than 5 days, and the drug release can reach 48% in about 2 days.

[0054] In the blood drug concentration experiment, a total of 3 groups of BALB / C mice were used, 3 in each group, w...

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Abstract

The invention belongs to the technical field of biomedical materials, and relates to application of curcumin solid lipid nano-particles. After traditional Chinese medicament curcumin is loaded with solid nano-lipisome, the syringeability of curcumin can be improved, the bioavailability of curcumin can be improved by about 30 times, and the lung targeting of curcumin can be improved. The SLN-curcumin can be used for effectively treating asthma to recover the airway resistance to a normal level, is safe, does not have remarkable toxic or side effect, and has great market developing potentials. The reaction system related in the invention is relatively stable, the technical operation is simple, the product treatment is especially convenient and convenient, and industrialization can be favored.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to the application of curcumin solid lipid nanoparticles. Background technique [0002] Curcumin is a commonly used traditional Chinese medicine. It is safe and non-toxic, and has obvious curative effect on asthma. However, curcumin is insoluble in water, hardly soluble in oil, and only soluble in some organic solvents. The absorption and utilization of curcumin by organisms is very low. It is less than 1% of the administration, and the utilization varies greatly among individuals, which also brings great restrictions to the application of curcumin. In order to solve the problems of poor bioavailability and difficult administration of curcumin, and develop it into a new drug for treating and controlling asthma, it is necessary to introduce a suitable drug-loading system, which is also a popular field of curcumin research in recent years. At present, there are many drug-l...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/12A61P11/06
Inventor 汪世龙朱融融王文锐
Owner TONGJI UNIV
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