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Antiallergic drug with lettuce as an active ingredient

An active ingredient and anti-allergic drug technology, applied in the field of food or pharmaceutical compositions, can solve the problems of no specific research on lettuce and the lack of anti-allergic effect, achieve significant improvement and treatment of symptoms, excellent safety, The effect of improving allergy symptoms

Active Publication Date: 2016-01-13
大森健康管理株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, its anti-allergic effect is not enough to relieve allergic symptoms
In addition, although experiments on cruciferous plants such as broccoli and cabbage are also described, there is no specific research on lettuce, which is a completely different family of plants, etc.

Method used

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  • Antiallergic drug with lettuce as an active ingredient
  • Antiallergic drug with lettuce as an active ingredient
  • Antiallergic drug with lettuce as an active ingredient

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0089] Example 1: Evaluation of anti-allergic effect of freeze-dried lettuce

[0090] The antiallergic effect of lettuce was evaluated using allergic rhinitis model mice (allergen-sensitized mice).

[0091] (1) Preparation of lettuce suspension

[0092] Preparation of freeze-dried lettuce

[0093] Wash fresh lettuce with water to remove foreign matter such as soil. Divide it into stems and leaves. The stems are peeled off with a peeler (thickness 5-8mm), and the edible part of emerald color is used as raw materials, and the leaves are directly used as raw materials. Stems and leaves are blanched for 1 to 5 minutes with hot water at 80 to 100°C with 1 to 5% salt added. The purpose of blanching is to inhibit the enzyme activity contained in lettuce and reduce the number of bacteria. Immediately after blanching, the stems and leaves are put into cold water and cooled to below 30°C. Use a centrifugal dehydrator (NE3-26, manufactured by ASAHI Manufacturing Co., Ltd.) to centri...

example 2

[0109] Example 2: Evaluation of anti-allergic effect of freeze-dried lettuce (histamine-induced mice)

[0110] As the anti-allergic effect of lettuce, using mice inoculated with histamine, that is, histamine-induced mice, inhibitory effect on histamine-induced rhinitis symptoms, inhibitory effect on histamine-induced skin itching behavior, and histamine-induced skin vascular hyperpermeability Response inhibition was evaluated.

[0111] (1) Evaluation of the inhibitory effect of histamine-induced rhinitis symptoms

[0112] In mice with rhinitis induced by histamine, in the test groups administered with lettuce suspension (lettuce stem administration group, lettuce leaf administration group), cetirizine administration group as an antihistamine, and control group Determination of histamine-induced rhinitis symptoms.

[0113] Put 5-week-old female ICR mice (obtained from Japan SLC Co., Ltd.) under the conditions of room temperature 24±2°C, humidity 55±15%, and light-dark cycle f...

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PUM

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Abstract

Provided is an anti-allergic medicine which is capable of preventing allergic diseases expecially preventing attacks of I-type allergic diseases, helps to further improve and treat symptoms, exhibits excellent safety and causes low possibilities of side effects. According to the invention, the anti-allergic medicine, allowing herbs or a part of asparagus lettuce to serve as an effective component, has functions of prevention, improvement and treatment for the allergic diseases.

Description

technical field [0001] The present invention relates to the antiallergic drug which uses the whole herb or a part of lettuce as an active ingredient. The present invention also relates to a food or pharmaceutical composition comprising the above-mentioned antiallergic drug. Background technique [0002] In recent years, allergic diseases have been rapidly increasing not only in Japan but also in the whole world. In particular, allergies such as allergic rhinitis, hay fever, atopic dermatitis, and bronchial asthma are called type I allergies (immediate allergies), and their prevalence is increasing year by year, becoming a major social problem. [0003] Conventionally, steroid drugs, antihistamines, and the like have been used in the treatment of allergic diseases. However, since allergic diseases are difficult to be completely cured, continuous medication is necessary, and administration of the above-mentioned chemical drugs is likely to cause side effects. Therefore, peo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A23L1/29A61P37/08A23L33/00
Inventor 赵秋娥杉本幸雄
Owner 大森健康管理株式会社