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Hydrogel applicable to angiostomy and preparation method thereof

A technology of hydrogel and anastomosis, which is applied in the field of hydrogel containing poloxamer and hydroxyethyl starch and its preparation, and achieves the effects of good blood cell compatibility, high cost performance, and increased sealing performance

Inactive Publication Date: 2014-12-17
ZHEJIANG HISUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on hydroxyethyl starch combined with poloxamer, after repeated experiments, the inventor prepared a hydrogel containing poloxamer and hydroxyethyl starch for vascular anastomosis, which solved the problem of existing microscopic problems. The weak point of bonding method in the vascular anastomosis, the technical scheme that the present invention adopts is as follows

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Preparation of Hydrogel Containing Poloxamer 338 and Hetastarch 40

[0023] In this example, poloxamer 338 and hydroxyethyl starch 40 were selected as raw materials, and organic weak acid citric acid was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.

[0024] Preparation of hydrogel containing poloxamer 338 and hydroxyethyl starch 40: Weigh 0.01 g of hydroxyethyl starch 40, disperse it in 10 ml of water for injection, dissolve it in a water bath at 30 ° C, add 3.0 g of poloxamer 338 and Shake or stir 0.01 g of citric acid in a water bath at 20°C until completely dissolved to form a hydrogel, freeze-dry to obtain a freeze-dried powder, fill in sterile vials, and seal. Before use, add 10ml of water for injection and shake slightly to form a hydrogel.

Embodiment 2

[0025] Example 2, Preparation of Hydrogel Containing Poloxamer 188 and Hetastarch 130 / 0.4

[0026] In this example, poloxamer 188 and hydroxyethyl starch 130 / 0.4 were selected as raw materials, and glycine was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.

[0027] Preparation of hydrogel containing poloxamer 188 and hydroxyethyl starch 130 / 0.4: Weigh 0.025g of hydroxyethyl starch 130 / 0.4 and disperse it in 10ml of water for injection, dissolve it in a water bath at 30°C, add 2.5g of polox Sharm 188 and 0.2g glycine were shaken or stirred in a water bath at 20°C until completely dissolved to form a hydrogel, filled into a sterile syringe, and sealed.

Embodiment 3

[0028] Example 3, Preparation of Hydrogel Containing Poloxamer 407 and Hetastarch 130 / 0.4

[0029] In this example, poloxamer 407 and hydroxyethyl starch 130 / 0.4 were selected as raw materials, and an anticoagulant heparin was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.

[0030] Preparation of hydrogel containing poloxamer 407 and hydroxyethyl starch 130 / 0.4: Weigh 0.1g of hydroxyethyl starch 130 / 0.4 and disperse it in 10ml of water for injection, dissolve it in a water bath at 30°C, add 1.6g of polox Sharm 407, 0.02ml of vascular endothelial growth factor (VEGF), 0.02ml of heparin (5000 units / ml), shake or stir in a water bath at 20°C until completely dissolved to form a hydrogel, fill in a sterile syringe, seal.

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Abstract

The invention discloses a poloxamer and hydroxyethyl starch-containing hydrogel applicable to angiostomy and a preparation method of the hydrogel. The concentration of the poloxamer in the hydrogel is 10% (W / V)-30% (W / V), and the concentration of the hydroxyethyl starch is 0.1% (W / V)-2% (W / V). The hydrogel is previously enveloped into a sterilized syringe or an ampoule, or the hydrogel is dried in a freezing way to form into freeze-dried powder to be poured into a penicillin bottle, and water for injection is added for dissolving before the hydrogel is used, so that the hydroxyethyl can be formed. The poloxamer and hydroxyethyl starch-containing hydrogel provided by the invention is applicable to the angiostomy, and the support or stitches assistant in a soluble blood vessel does not need, so that the seal performance of an anastomotic stoma can be increased, the hydrogel is free from leakage phenomenon, and the risk of the wound and the thrombosis in the process of angiostomy can be reduced.

Description

【Technical field】 [0001] The invention relates to a hydrogel used in vascular anastomosis in vascular surgery and its preparation, in particular to a hydrogel containing poloxamer and hydroxyethyl starch used in vascular anastomosis and a preparation method thereof. 【Background technique】 [0002] In recent years, with the gradual increase in the incidence of vasodilatory diseases, vascular occlusive diseases, and vascular injuries, higher requirements have been put forward for the techniques of vascular grafting, vascular suture and repair. The anastomotic technique of small blood vessels and microvessels is directly related to the survival of tissues and organs at the distal end of blood vessels, and plays an important role in the fields of vascular surgery and microsurgery. With the continuous development of microsurgery, the requirements for vascular anastomosis technology are constantly increasing, not only must there be a good immediate patency rate, but also a better ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/30A61L24/04
Inventor 鲁翠涛赵应征赵子逸
Owner ZHEJIANG HISUN PHARMA CO LTD