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Method for continuously synthesizing cumarin by microchannel reactor

A micro-channel reactor, coumarin technology, applied in the field of chemical synthesis and technology, can solve the problems of complex process, long production cycle, pollution of the environment, etc., and achieve the effects of high product conversion rate, short reaction time, and overcoming large dosage.

Active Publication Date: 2013-03-27
NANJING UNIV OF TECH
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for continuously synthesizing coumarin in a microchannel reactor, so as to overcome the defects of the traditional reaction bottle (kettle) and the large amount of acetic anhydride in the prior art, complicated process and long production cycle , Low product conversion rate and yield, high cost, environmental pollution and other disadvantages

Method used

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  • Method for continuously synthesizing cumarin by microchannel reactor
  • Method for continuously synthesizing cumarin by microchannel reactor

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Embodiment 1~19

[0030] The catalyst is dissolved in the mixed solution of acetic anhydride and acetic acid, the mass ratio of acetic anhydride, acetic acid and catalyst is m 1 :m 2 :m 3 ; Salicylaldehyde and the above-mentioned mixture according to the flow volume ratio V 1 :V 2 Pumped into the microchannel reactor respectively, successively pass through the reactor I and the reactor II connected in series in the microchannel reactor, the total residence time in the reactor I and the reactor II is respectively t, and the reaction temperature is respectively T 1 and T 2 ; Microchannel reactor output refining (including conventional vacuum distillation and recrystallization, etc.) to obtain coumarin products. The specific conditions and results of the EHRFELD slit-plate mixer reactor are shown in Table 1. For the Vapourtec R4 / R2+ reactor, only V 1 and V 2 are all halved, other conditions are the same as in Table 1, and the reaction effect is almost equivalent to that of the EHRFELDslit-pl...

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Abstract

The invention discloses a method for continuously synthesizing cumarin by a microchannel reactor, comprising the following steps: (1) dissolving a catalyst into a mixed solution of acetic anhydride and acetic acid, wherein the mass ratio of the acetic anhydride to the acetic acid to a catalyst is (15-50): (2-5):1; (2) respectively pumping salicylaldehyde and the mixture obtained in step (1) in the volume ratio of 1: (1-2) into the microchannel reactor, and enabling the mixture to pass through a reactor I and a reactor II connected in series, wherein the total dwell time of the mixture in the reactor I and the reactor II lasts for 20-80 min; and (3) refining the discharged material to obtain a cumarin finished product. By using the method, tower and kettle devices are avoided, and the method is short in reaction time, low in raw material consumption per unit, high in conversion rate and yield, low in cost and suitable for industrial application.

Description

technical field [0001] The invention relates to a method for continuously synthesizing coumarin with a microchannel reactor, belonging to the field of chemical synthesis and technology. Background technique [0002] Coumarin is an important spice with a wide range of applications. It is often used as a deodorant for the preparation of perfumes, soaps and cosmetics. It is also used as a flavor enhancer for rubber and plastic products. It can also be used as a pharmaceutical intermediate and metal surface Processing abrasives and brighteners. In addition, because coumarin derivatives have unique biological and physiological properties, such as antibacterial, anticoagulant, hypotensive, and hypoglycemic effects, especially some derivatives have anti-HIV activity and anti-tumor activity. Research is gaining more and more attention. [0003] At present, coumarin is produced in tower kettles in industry. The main disadvantages of this method are: large investment in equipment, l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/10
Inventor 郭凯周扬志李昕何伟欧阳平凯
Owner NANJING UNIV OF TECH
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