Sulfobutyl-alpha-cyclodextrin and preparation method thereof

A technology of cyclodextrin and sulfobutyl, which is applied in the field of sulfobutyl-α-cyclodextrin and its preparation, can solve the problems of application limitation and low solubility of α-cyclodextrin, and achieve strong stability and water solubility Good, operable effect
CN102993338BActive Publication Date: 2015-06-10SHAANXI UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI UNIV OF SCI & TECH
Publication Date
2015-06-10

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Abstract

The invention provides sulfobutyl-alpha-cyclodextrin and a preparation method thereof. The structural formula of the sulfobutyl-alpha-cyclodextrin is shown in the specification, wherein R=H, and the molecular weight is 1,108.17-2,605; and the sulfobutyl-alpha-cyclodextrin is prepared by the reaction of 1,4-butanesultone and alpha-cyclodextrin in a strong alkali solution. The water solubility of the sulfobutyl-alpha-cyclodextrin provided by the invention reaches 80g at 20 DEG C and is improved by 4 times over the existing alpha-cyclodextrin. The preparation method of the sulfobutyl-alpha-cyclodextrin provided by the invention is simple and has high reaction efficiency; the prepared sulfobutyl-alpha-cyclodextrin has strong stability and good water solubility; the whole preparation method has strong operability; and the sulfobutyl-alpha-cyclodextrin can be conveniently prepared into various guest molecule inclusion compounds and compositions.
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Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis, and relates to a sulfobutyl-alpha-cyclodextrin and a preparation method thereof. Background technique

[0002] Cyclodextrin was first discovered in 1891. In 1903, Schardinger obtained α-cyclodextrin by digesting starch with an isolated strain. α-cyclodextrin is a white crystal, and the crystal formed in water is a needle-like crystal, and its solubility in water increases with the increase of temperature. Due to the low solubility of α-cyclodextrin, which is 14.5g at room temperature, and its small molecular cavity, the application of α-cyclodextrin is limited. Contents of the invention

[0003] The object of the present invention is to provide a sulfobutyl-α-cyclodextrin to solve the problem that the application of the existing α-cyclodextrin is limited due to its low solubility.

[0004] The object of the present invention is achieved like this, sulfobutyl-alpha-cyclodextrin, its...

Claims

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