Auxiliary reagent for ISE module of biochemical analyzer

Abstract

The invention discloses an auxiliary reagent for an ISE module of a biochemical analyzer. The auxiliary reagent comprises an internal standard solution, a reference solution and a diluent, wherein an osmotic pressure of the internal standard solution, the reference solution and the diluent is 55-2,000 mOsm / kg H2O; the internal standard solution is a water solution containing 1,3-bis[tris(hydroxymethyl)methylamino]propane, boric acid, sodium chloride, potassium dihydrogen phosphate, potassium chloride and a ProClin300 biological preservative; the reference solution is a water solution containing potassium chloride and the ProClin300 biological preservative; and the diluent is water solution containing 1,3-bis[tris(hydroxymethyl)methylamino]propane, boric acid and the ProClin300 biological preservative. The auxiliary reagent is low in cost, and is basically identical with a Hitachi original reagent in various components and physicochemical indexes; and measurement results have good relativity. The precision, accuracy, linearity range and stability of the auxiliary reagent meet requirements; phenomena such as electrode damages or pipeline obstructions and the like are not found in experimental use of six months. A quality guarantee period of the auxiliary reagent is longer than two years.

Description

technical field [0001] The invention relates to the technical field of medical reagents, in particular to a matching reagent for an ISE module of a biochemical analyzer. Background technique [0002] The ISE (Ion Selective Electrode) module on large-scale biochemical analyzers has been widely used in the field of clinical biochemistry. ISE methods can be divided into direct ISE assays and indirect ISE assays. The ISE module on the large-scale biochemical analyzer mostly uses the indirect ISE measurement method: the sample and the standard solution should be quantitatively diluted with a buffer solution with a specified ionic strength and pH value, and then enter the electrode pipeline to measure its potential. It should be noted that compared with the direct ISE assay, the test results of the indirect ISE assay will be lower, because in the indirect ISE assay, a certain volume of total plasma is diluted, but in fact only 93% of the plasma water ( containing electrolytes) wa...

AI Technical Summary

Problems solved by technology

[0003] At present, most of the medium-sized and large hospitals in China use full / semi-automatic biochemical analyzers, and basically use the original matching cleaning solution, but the reagent consumption of this type of instrument is large, and the price of the original matching is expensive, which increases the Hospital testing costs, thus indirectly increasing the burden on patients

Using the existing self-prepared reagents in the domestic market, the phenomenon of abnormal results returning to normal after re-examination is significantly more than when using the original reagents. This may be due to the poor effect of the self-prepared reagents or interference with certain test items.

And some self-prepared reagents are too corrosive, which will easily corrode many metal parts of the instrument.

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