Anti-depression application of acanthopanax obovatus hoo and medicine prepared from acanthopanax obovatus hoo

An antidepressant technology, applied in the field of antidepressant drugs, can solve the problems of difficulty in obtaining a satisfactory curative effect, large adverse reactions, narrow antidepressant spectrum, etc., and achieves significant therapeutic effect, good therapeutic effect, and exact drug effect. Effect

Inactive Publication Date: 2013-04-03
陕西中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, drug treatment mainly adopts chemical drug treatment, most of which have defects such as narrow antidepressant spectrum, targeting a single link, relatively large adverse reactions, high drug prices and easy relapse, and it is often difficult to obtain satisfactory curative effect

Method used

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  • Anti-depression application of acanthopanax obovatus hoo and medicine prepared from acanthopanax obovatus hoo
  • Anti-depression application of acanthopanax obovatus hoo and medicine prepared from acanthopanax obovatus hoo
  • Anti-depression application of acanthopanax obovatus hoo and medicine prepared from acanthopanax obovatus hoo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 The preparation of the water extract of Acanthopanax ovalifolia:

[0034] Take the Chinese herbal medicine, crush it, add water and decoct three times, add 10 times the amount of the medicinal material for the first time and decoct for 1 hour, add 8 times the amount of water for the second time and decoct for 1 hour, and add 8 times the amount of water for the third time Decoct for 0.5 hours, combine the decoction liquid, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.30 to 1.35 (measured at 55°C), dry under vacuum and reduce pressure, and pulverize into fine powder to obtain Acanthopanax ovale with water. dry powder.

Embodiment 2

[0035] The preparation of embodiment 2 obversia acanthus ethanol extract

[0036] Take the medicinal material of Acanthopanax ovalifolia, break it, add 10 times the mass of 60% ethanol to heat and reflux extraction, each time for 1 hour, collect the extract, let it stand, filter, recover the ethanol under reduced pressure and concentrate to a relative density of 1.12 (50 ~60°C), spray-dried to obtain the ethanol extract of Acanthopanax ovalifolia.

Embodiment 3

[0037] Example 3 Preparation of the extract of Acanthus ovalifolia with water extraction and alcohol precipitation

[0038] Take the Argonaus ovata medicinal material, crush it, add water to decoct twice, add 10 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 0.5 hours for the second time, combine the decoction liquid, filter, Concentrate under reduced pressure to a relative density of 1.25-1.30 (55°C), let it cool, add ethanol to make the alcohol content reach 65%, let stand for 24 hours, take the supernatant to recover ethanol under reduced pressure and concentrate to a relative density of 1.30-1.35 (measured at 55°C), vacuum-dried under reduced pressure, and pulverized to obtain a powder of Acanthopanax ovalifolia plus water extraction and alcohol sinking.

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PUM

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Abstract

The invention discloses an anti-depression application of acanthopanax obovatus hoo and a medicine prepared from the acanthopanax obovatus hoo, expands a new medical application of the acanthopanax obovatus hoo and provides a new medical source for preventing and treating depression. Extract of the acanthopanax obovatus hoo has a good anti-depression effect and can improve mental and neural states; and the extract of the acanthopanax obovatus hoo takes effect quickly and has no toxic or side effect, high safety and obvious health care and treatment effect.

Description

technical field [0001] The invention belongs to the technical field of antidepressant drugs, and relates to the antidepressant application of Acanthopanax ovalifolia and the prepared drug. Background technique [0002] Depression belongs to the category of mental illness, which is an affective and mental disorder caused by the dysfunction of the central nervous system. Somatic symptoms are the main group, leading to slow thinking, pessimism and despair, and loss of ability to control normal activities in severe cases. It is characterized by high disability rate, high recurrence rate, and high disease burden. At the same time, depression is a common disease with a high incidence in modern society, and its incidence is rising rapidly. Globally, the number of people who have experienced some kind of mental and nervous discomfort in their lifetime has reached 450 million. Mild depression can be well recovered with psychotherapy and strengthening sports, and severe depression mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P25/24A23L1/29A23L33/00
Inventor 朱爱华同卓斌杨钧张艺芳何爱武
Owner 陕西中药研究所
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