Medium and long chain fat emulsion injection and preparation method thereof

A long-chain fat emulsion and injection technology, applied in the field of medicine, can solve problems such as fat accumulation, human immune function and adverse effects on liver function

Active Publication Date: 2013-04-03
LIAONING HAISCO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these long-chain fat emulsions still have some side effects such as adverse effects on human immune function and liver function in clinical application, and fat may accumulate in the liver.

Method used

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  • Medium and long chain fat emulsion injection and preparation method thereof
  • Medium and long chain fat emulsion injection and preparation method thereof
  • Medium and long chain fat emulsion injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0043] Experimental example 1-the selection of colostrum temperature in the present invention

[0044] Weigh soybean oil and medium-chain triglycerides, stir and mix evenly, heat to 60°C, 70°C, and 80°C respectively, add lecithin, and stir quickly until uniform. Separately take water for injection and add glycerin, stir evenly, heat to 60°C, 70°C, and 80°C respectively, slowly add phospholipid oil solution into glycerin aqueous solution under rapid stirring to form colostrum, and homogenize through a high-pressure homogenizer (700bar) After 6 times, the appearance and shape were observed with naked eyes. See Table 1 and Table 2 for the results.

Embodiment 1

[0046] Oil phase temperature (°C) Water phase temperature (°C) Appearance shape 60 60 There are > 10 oil droplets on the liquid surface 70 70 Uniform milky white, no oil droplets on the liquid surface 80 80 There are

[0047] It can be seen from Table 1 that increasing the temperature (70°C) can promote the molding of Example 1, but an excessively high temperature will affect the stability of the entire system.

Embodiment 2

[0049] Oil phase temperature (°C) Water phase temperature (°C) Appearance shape 60 60 There are > 10 oil droplets on the liquid surface 70 70 Uniform milky white, no oil droplets on the liquid surface 80 80 There are

[0050] Can know from table 2: the result of embodiment 2 is identical with embodiment 1, so when preparing the colostrum of embodiment 1 and embodiment 2, temperature should be controlled at 70 ℃ of phospholipid oil solution, 70 ℃ of aqueous glycerin.

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Abstract

The invention aims to provide a medium and long chain fat emulsion injection and a preparation method thereof. Specifically, every 1,000 ml of the medium and long chain fat emulsion injection contains 50 to 100 grams of soybean oil for injection, 50 to 100 grams of medium chain triglycerides for injection, 12 grams of lecithin for injection, 25 grams of glycerin for injection and an appropriate quantity of water. By adopting a large quantity of process screening operations and combining pilot scale production, process conditions for a special prescription are determined to fully guarantee the effectiveness, controllability and stability of a product.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medium / long-chain fat emulsion injection and a preparation method thereof. Background technique [0002] Lipid emulsion (LE) is an important part of parenteral nutrition and a product of clinical nutrition development. It has been more than 40 years since Wretlind first applied fat emulsion to clinical practice in 1961. Great changes have taken place in the types and compositions of LE, and medium / long-chain fat emulsion, structured fat emulsion, and fish oil fat emulsion have been introduced successively. Injections, etc.; its clinical application has also expanded from a single supply of energy and essential fatty acids to adjuvant treatment of various systemic diseases and the field of drug production. The advent of LE embodies the high-tech research results and has become an indispensable ingredient in nutritional preparations. It plays a very important role i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/107A61P3/02A61K31/685A61K31/23
Inventor 郑伟
Owner LIAONING HAISCO PHARMACEUTICAL CO LTD
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