Method for preparing salvianolic acid A through catalytically converting salvianolic acid B
A technology of catalytic conversion and salvianolic acid, which is applied in the preparation of carboxylic acid esters, chemical instruments and methods, and the preparation of organic compounds, to achieve the effects of improving conversion rate, simple preparation process, and simple production process
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Embodiment 1
[0044] Take 25kg of Danshen medicinal pieces, add 8 times the amount of water each time, warm immersion and extract at 80 ° C for 1.5 hours, while stirring at a speed of 10-15 r / min, warm immersion, stir and extract 3 times in total, filter, combine the filtrate, and the extract is reduced. Press and concentrate to a relative density of 1.20 (60°C), add ethanol to make the alcohol content at 70%, let stand for 12 hours, filter, recover ethanol under reduced pressure from the filtrate and concentrate to no alcohol smell, add water to dilute to 25000ml, and measure the salvianol The content of acid B was 42.0 mg / ml, and the salvia miltiorrhiza extract was obtained, which was refrigerated and placed for later use.
Embodiment 2
[0046] Take 25kg of Salvia miltiorrhiza medicinal materials, pulverize them into particles with a diameter of about 2mm, add 9 times the amount of water each time, warm immersion and extract at 85 ° C for 2 hours, while stirring at a speed of 15-25 rpm, a total of 2 times of warm immersion, stirring and extraction, filter, The filtrates were combined, the extract was concentrated under reduced pressure to a relative density of 1.10-1.25 (60° C.), ethanol was added to make the alcohol content at 75%, allowed to stand for 12 hours, filtered, the filtrate was decompressed to recover ethanol and concentrated to no alcohol smell, and water was added. It was diluted to 25000ml, and the content of salvianolic acid B was measured to be 40.0mg / ml, and the extract of Salvia miltiorrhiza was obtained, which was refrigerated and kept for later use.
Embodiment 3
[0048] Take 30kg of salvia miltiorrhiza pieces, add 10 times the amount each time, decoct and extract for 2 hours each time, and extract 3 times in total; the extract is concentrated under reduced pressure to a relative density of 1.10-1.20 (60°C), and ethanol is added to make the alcohol content in the 70%, filtered, the filtrate was decompressed to recover ethanol and concentrated to no alcohol smell, diluted with water to 25000ml, the content of salvianolic acid B was measured to be 45.0mg / ml, and the salvia miltiorrhiza extract was obtained, refrigerated and kept for later use.
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