Drug composition containing docetaxel compound

Abstract

The invention provides a drug composition containing a docetaxel compound. The drug composition comprises docetaxel, tween-80, polyoxyethylene castor oil, citric acid and enthanol. A preparation method comprises the following steps: adding polyoxyethylene castor oil, citric acid and enthanol into tween-80, mixing uniformly, adding docetaxel, dissolving, and mixing uniformly to form a homogeneous and clear liquid. According to the drug composition, as docetaxel, tween-80, polyoxyethylene castor oil, citric acid and enthanol are compounded, the problem of poor dissolvability of docetaxel is effectively solved; the drug composition is high in qualification rate and good in long term stability; and as docetaxel is not precipitated easily when an infusion solution is added, the drug safety is improved. In addition, as the use amount of tween-80 is reduced, the hemolysis risk caused by tween-80 can be reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating malignant tumors, and also to a preparation method thereof. Background technique [0002] Malignant tumors are due to the mutation of cells in the body, resulting in uncontrolled cell division and inability to undergo programmed apoptosis, which eventually lead to a large number of such cells proliferating, disrupting the normal order of the human body, occupying a large amount of nutrients in the human body, resulting in the decline of human body functions, and causing various complications , eventually leading to death. [0003] Surgical removal of the tumor is the treatment of choice. However, cancer cells can pass out of the tumor and enter the blood or lymphatic system, thereby forming new tumors from the original site to other organs. This process is called cancer metastasis. When cancer metastasizes, cancer cells often metastasiz...

AI Technical Summary

Problems solved by technology

[0007] Patent document CN101862319B discloses a docetaxel composition for injection, which solves the precipitation of docetaxel produced in the process of evaporating ethanol by adjusting the preparation process, but it also does not give To overcome the problem of docetaxel precipitation when it is added to normal saline at the time of administration

At the same time, the process is complicated, and the long-term stability has not been investigated.

[0008] The above problems directly affect the drug safety of docetaxel and hinder the popularization and application of docetaxel

At present, there is no relevant report on effectively solving this problem

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