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A kind of carboxymethyl lactose and its preparation method and application

A technology of carboxymethyl lactose and lactose, which is applied in the field of daily chemicals, can solve the problems that hyaluronic acid cannot meet market needs, and achieve the effects of improving moisture absorption and moisturizing performance, reducing production costs, and simple synthesis steps

Active Publication Date: 2015-12-23
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the above reasons, hyaluronic acid cannot meet the needs of the market

Method used

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  • A kind of carboxymethyl lactose and its preparation method and application
  • A kind of carboxymethyl lactose and its preparation method and application
  • A kind of carboxymethyl lactose and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Carboxymethyl lactose is a compound shown in formula one.

[0026] Preparation of carboxymethyl lactose: Add 1.8g of lactose (see Formula 1) to 20mL of isopropanol and stir to swell at room temperature for 30min, then add 6ml of 10mol / L sodium hydroxide solution, stir and react at 40°C for 3h, then add chlorine 1.8g of acetic acid was reacted at 60°C for 12h. After the reaction, it was neutralized with acetic acid to neutrality, then precipitated with methanol, filtered with suction, washed with 50mL of methanol and 50mL of ethanol for 3 times, filtered with suction, and vacuum freeze-dried to obtain Pale yellow product carboxymethyl lactose (see figure 2 ). Carboxymethyl lactose is light yellow powder or solid, easily soluble in cold and boiling water without being pasty, transparent liquid, slightly soluble in ethanol.

[0027] Wherein lactose (lactose) is 4-O-β-D-galactopyranosyl-D-glucose.

[0028] From figure 2 It can be seen that compared with lactose raw ma...

Embodiment 2

[0030] The difference from Example 1 is:

[0031] Add 1.8g of lactose to 20mL of isopropanol, stir and swell at room temperature for 60min, then add 6ml of 10mol / L sodium hydroxide solution, stir and react at 40°C for 3h, then add 1.8g of chloroacetic acid and react at 50°C for 16h, in acetic acid After being neutralized, it was precipitated with methanol, filtered with suction, washed with 50 mL of methanol and 50 mL of ethanol in sequence, filtered with suction, and vacuum freeze-dried to obtain carboxymethyl lactose.

Embodiment 3

[0033] The difference from Example 1 is: add 1.8g of lactose to 20mL of isopropanol, stir and swell at room temperature for 30min, then add 6ml of 10mol / L sodium hydroxide solution, stir and react at 40°C for 6h, and then add 1.8g of chloroacetic acid Reacted at 60°C for 16 hours, neutralized to neutral with acetic acid, precipitated with methanol, filtered with suction, washed with 50mL of methanol and 50mL of ethanol in turn, filtered with suction, and vacuum freeze-dried to obtain carboxymethyllactose.

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Abstract

The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to carboxymethyl lactose and its preparation method and application. Carboxymethyllactose is shown in Formula 1. React lactose and sodium hydroxide solution in isopropanol solution at 40-50°C for 2.5-3h, then add chloroacetic acid and react at 50-60°C for 10-18h. That is, carboxymethyl lactose is obtained; the molar amount of the added sodium hydroxide is 3-4 times that of lactose, and the molar amount of added chloroacetic acid is 2-3 times that of lactose. The carboxymethyl lactose can be used as a hygroscopic humectant. The carboxymethyl lactose obtained by the effective synthesis method of the present invention makes the lactose that originally has no moisture absorption and moisturizing ability into carboxymethyl lactose with good moisture absorption and moisturizing ability, so that it can be used as hyaluronic acid, an expensive moisturizing agent in cosmetic moisturizing agents. Alternative to acid, greatly reducing costs.

Description

technical field [0001] The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to carboxymethyl lactose and its preparation method and application. Background technique [0002] Lactose is a kind of disaccharide, the molecular formula is C12H22O11, it is a disaccharide in mammalian milk, hence the name. Its molecular structure is formed by the condensation of a molecule of glucose and a molecule of galactose. The taste is slightly sweet, with about 4% lactose in cow's milk and 5% to 7% in human milk. Extracted from whey in industry, it is used in the manufacture of baby food, candy, artificial milk, etc. It is often used as a flavoring agent in medicine. [0003] Extracted from whey in industry, it is used in the manufacture of baby food, candy, artificial milk, etc. It is often used as a flavoring agent in medicine. [0004] This product is white crystalline granules or powder; odorless, slightly sweet taste. Soluble in wat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/04C07H1/00B01F17/56C09K23/56
Inventor 郭占勇冯艳任剑明
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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