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Traditional drug toxicity evaluation method and system thereof

A traditional drug and evaluation method technology, applied in the field of computer-aided drug toxicity evaluation method and its system, can solve problems such as doubtful accuracy, large dosage of general drugs, and inability to achieve high-throughput quantification, so as to achieve accurate evaluation and prediction, and save money and the effect of time

Inactive Publication Date: 2013-04-17
北京东方灵盾科技有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the means of detecting the toxic and side effects of drugs is mainly through animal experiments, such as experiments on mice, rabbits, dogs, monkeys, zebrafish, etc., but the price is expensive, and the general amount of medicine is relatively large, so high-throughput cannot be achieved; cell-level experiments can also be used for Drug toxicity detection, such as detecting the pathogenic effect of drugs on receptors by patch clamp technology, but the results of the cell level and clinical trials are quite different, and the accuracy is doubtful

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  • Traditional drug toxicity evaluation method and system thereof
  • Traditional drug toxicity evaluation method and system thereof
  • Traditional drug toxicity evaluation method and system thereof

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Embodiment 1

[0026] Embodiment one provides a kind of qualitative evaluation method of traditional drug toxicity, in conjunction with the attached figure 1 And attached figure 2 The principles and methods of the present invention are described.

[0027] The evaluation method of traditional drug toxicity of the present invention comprises the following steps:

[0028] (1) Determine the chemical composition of the traditional medicine to be evaluated: first determine the composition of the traditional medicine; then determine its corresponding chemical composition according to the composition of the traditional medicine;

[0029] (2) Evaluate the toxicity of the traditional medicine according to its chemical composition.

[0030] In the first step, first determine the medicinal ingredients contained in the traditional medicine. The traditional medicine to be tested can be only a single medicine, or a composition composed of multiple traditional medicines. It is determined according to the...

Embodiment 2

[0041] This embodiment is about the embodiment of the traditional drug toxicity evaluation and prediction system of the present invention.

[0042] figure 1 Shown is the structure and schematic diagram of a preferred embodiment of a traditional drug toxicity evaluation and prediction system of the present invention. A kind of traditional drug toxicity evaluation prediction system 100 of the present invention comprises:

[0043] (1) Input module 110, used for inputting and analyzing traditional medicine and traditional medicine prescription information, and responding to various operations of users; (2) Output module 120, used for displaying calculation process information, and summarizing and outputting prediction results ; (3) storage module 140, used to store, read and manage computer program files, compound structure files, activity data files, configuration files, temporary files and historical files; (4) traditional medicine database, used to store and manage traditional...

Embodiment 3

[0047] The third embodiment is another preferred embodiment using the system and method for evaluating and predicting the toxicity of traditional drugs of the present invention. combined with figure 1 To be explained as follows.

[0048] like figure 1 In the evaluation and prediction system 100 of traditional drug toxicity of the present invention, the evaluation and prediction system 100 of traditional drug toxicity of the present invention is at least composed of the following parts: (1) an input module 110; (2) an output module 120; (3) a Data processing module 130; (4) a storage module 140; (5) a feature structure identification module 150; (6) a traditional medicine natural product database 160; (7) a compound structure similarity evaluation module 170; (8) a Toxic Compound Library180. Each module works synergistically to complete the input, storage, and compound toxicity prediction and result output of traditional drug names.

[0049] Firstly, the attributes and func...

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Abstract

The invention provides a traditional drug toxicity evaluation method and a system thereof. A qualitative forecasting method comprises the following steps of: (I) determining the chemical components of a to-be-evaluated traditional drug; and (II) evaluating the toxicity according to the chemical components of the traditional drug. An evaluation forecasting system at least comprises an input module, an output module, a storage module, a traditional drug database, a toxic compound library, a compound toxicity forecasting module and a data processing module. The system and method can accurately forecast the toxicity risk of the drug in research in time for development of a traditional drug, and greatly save money and time; and the system and method provided by the invention also can be used for improving the formula of a traditional drug. The framework of the system provided by the invention has good flexibility and expandability, and can be conveniently used for forecasting other biological activities of the traditional drug.

Description

technical field [0001] The invention relates to a computer-aided drug toxicity evaluation method and system thereof, in particular to a traditional drug toxicity evaluation method and system thereof. Background technique [0002] The safety of drugs has always been concerned in the clinical application of drugs. Because traditional drugs, such as traditional Chinese medicine and Tibetan medicine, are derived from natural animals, plants, minerals and other substances, and often appear in drug applications in the form of compound prescriptions, their chemical The material basis and the mechanism of action of drugs in the human body are very complex, and its safety evaluation is very difficult. This is also one of the main obstacles for traditional drugs (such as traditional Chinese medicine, Tibetan medicine, etc.) to enter the international market, especially the hospital prescription market in Western countries one. [0003] The toxicity research and evaluation of traditio...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06F17/30
Inventor 刘延淮刘海波徐峻刘志强
Owner 北京东方灵盾科技有限公司
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