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Extraction method and obtained extractive and application of alkanet

An extraction method, the technology of comfrey root, applied in the field of natural medicinal chemistry, can solve the problems of harm to the body, large toxic and side effects, etc., and achieve the effect of low cost, easy operation and high extraction efficiency

Active Publication Date: 2014-07-30
ANHUI FENGYUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chemotherapy and radiotherapy are the main treatment methods for tumor treatment, and the radiation generated by radiotherapy will cause certain harm to the body, especially for tumor patients whose immune resistance is far lower than normal people, it is even more necessary to cooperate with a certain amount of anti-radiation medicine. medication for treatment
[0004] At present, most of the drugs used as anti-tumor adjuvant drugs are chemically synthesized drugs, which have relatively high toxicity and side effects. Therefore, it is very urgent to develop a natural anti-tumor adjuvant drug with no toxic side effects, high efficiency and easy availability.

Method used

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  • Extraction method and obtained extractive and application of alkanet
  • Extraction method and obtained extractive and application of alkanet
  • Extraction method and obtained extractive and application of alkanet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 comfrey root extract

[0036] Take 1 kg of comfrey root raw material, add 10 times the mass of ethanol until it is completely dissolved, add distilled water until the alcohol content is 50% (V / V), let it stand at a temperature of about 20°C for 24 hours, centrifuge, and collect the supernatant. For the precipitation part, repeat the above operation once more, and combine the supernatant obtained from the two operations to obtain the extract.

[0037] The obtained extract is filtered through an ultrafiltration membrane with a molecular weight cut-off of 13K to obtain a clear liquid and a concentrated liquid part, and the concentrated liquid part is diluted with 10 times the weight of water, and then filtered through a 13K ultrafiltration membrane to obtain the clear liquid. The liquid part was combined with the previous supernatant and concentrated to obtain a crude extract.

[0038] Dilute the obtained crude extract with water to a mass ...

Embodiment 2

[0041] The preparation of embodiment 2 comfrey root extract

[0042] Take 1 kg of comfrey root raw material, add 12 times the mass of ethanol until it is completely dissolved, add distilled water until the alcohol content is 40% (V / V), let it stand at a temperature of about 25°C for 20 hours, centrifuge, and collect the supernatant. For the precipitation part, repeat the above operation once more, and combine the supernatant obtained from the two operations to obtain the extract.

[0043] The obtained extract is filtered through an ultrafiltration membrane with a molecular weight cut-off of 13K to obtain a clear liquid and a concentrated liquid part, and the concentrated liquid part is diluted with 8 times the weight of water, and then filtered once through a 13K ultrafiltration membrane to obtain the clear liquid The liquid part was combined with the previous supernatant and concentrated to obtain a crude extract.

[0044] Dilute the obtained crude extract with water, the ma...

Embodiment 3

[0045] The preparation of embodiment 3 comfrey root extract

[0046] Take 1 kg of comfrey root raw material, add 6 times the mass of methanol until completely dissolved, add distilled water until the alcohol content is 50% (V / V), let it stand at a temperature of about 15°C for 30 hours, centrifuge, collect the supernatant, For the precipitation part, repeat the above operation twice, and combine the supernatant obtained from the three operations to obtain the extract.

[0047] The obtained extract is filtered through an ultrafiltration membrane with a molecular weight cut-off of 13K to obtain a clear liquid and a concentrated liquid part, and the concentrated liquid part is diluted with 5 times the weight of water, and then filtered once through a 13K ultrafiltration membrane to obtain the clear liquid The liquid part was combined with the previous supernatant and concentrated to obtain a crude extract.

[0048] Dilute the obtained crude extract with water to a mass percentage ...

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Abstract

The invention relates to an extraction method of alkanet. The extraction method of the alkanet comprises using low alcohol water solution to extract alkanet raw materials to obtain extracting solution, filtering the extracting solution by adopting of an ultrafiltration membrane, collecting clear liquid and concentrating to obtain a crude extract, diluting the crude extract, then separating the crude extract through macroreticular resin, collecting eluant and concentrating. The invention further relates to an obtained extractive and application of the extraction method. The invention further relates to a drug composition containing the extractive and application thereof. The extraction method is simple and convenient to operate, temperate in condition, low in cost, and high in extraction efficiency. Concentration of total flavone in the extractive achieves more than 50%. The total flavone in the alkanet extractive and the drug composition is high and has good radio-resistance effect.

Description

technical field [0001] The invention relates to the field of natural medicinal chemistry, in particular to an extraction method of comfrey root, the obtained extract and its application. Background technique [0002] Comfrey root is the root of Boraginaceae plant Comfrey, Xinzang pseudocomfrey or Yunnan comfrey. Modern pharmacological studies have shown that comfrey root has various physiological functions such as anti-oxidation, anti-bacteria, anti-inflammation, anti-tumor, and cardiovascular protection. active. Comfrey grows in barren hills, fields, roadsides and thickets on dry rocky hillsides, and is distributed in Xinjiang, Gansu and western Tibet. Northeast China and Hebei, Henan, Shanxi, Shaanxi, Ningxia, Qinghai, Shandong, Jiangsu, Anhui, Jiangxi, Hubei, Hunan, Guangxi, Sichuan, Guizhou and other places, so it has a wide range of sources and is a cheap and high-quality Chinese herbal medicine. So far, more than 130 kinds of compounds have been isolated and detected...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/30A61P17/16A61P35/00A61K125/00
Inventor 王艳郑嫣然余宏燕
Owner ANHUI FENGYUAN PHARM CO LTD