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A kind of method for enriching and purifying celandine in celandine

A technique of chelidine and celandine, which is applied to the purification of celandine, uses ultrasonic extraction-macroporous adsorption resin coupling method to enrich and purify the field of celandine in celandine, which can solve the problem of low extraction purity. , low extraction rate and other problems, to achieve the effect of high extraction purity, large adsorption capacity and rich source of raw materials

Inactive Publication Date: 2016-05-25
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying chelidonine in celandine by using ultrasonic extraction-macroporous adsorption resin coupling method

Method used

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Examples

Experimental program
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Effect test

Embodiment example 1

[0017] Implementation case 1: a method for enriching and purifying chelidonine in celandine by using ultrasonic extraction-macroporous adsorption resin coupling method, the steps are as follows:

[0018] (1) After 500g of dried celandine is crushed, cross a 60-mesh sieve, and extract with ultrasonic extraction, its concentration is 65% ethanol solution, the ratio of solid to liquid is 8 times of the crushed volume, the extraction temperature is 40°C, and the extraction frequency 60Hz, extraction time 1 hour, extraction 3 times;

[0019] (2) The celandine extract treated in (1) is combined, and the ethanol recovered under reduced pressure is concentrated to a relative density of 1.08;

[0020] (3) Adjust the pH value to 3.4 with 1mol / L phosphoric acid; refrigerate at 5°C for 48 hours and then suction filter. Adjust the pH value of the filtrate to 11 with 30% sodium hydroxide, extract 4 times with chloroform equivalent to the filtrate, combine the chloroform liquid, recover the...

Embodiment example 2

[0026] Implementation case 2: a method for enriching and purifying chelidonine in celandine by using ultrasonic extraction-macroporous adsorption resin coupling method, the steps are as follows:

[0027] (1) 70 mesh sieves are crossed after 500g dry celandine is pulverized, extract with ultrasonic extraction, its concentration is 70% ethanol solution, and solid-liquid ratio is 9 times of pulverized volume, and extraction temperature is 50 ℃, extraction frequency 80Hz, extraction time 1.5 hours, extraction 3 times;

[0028] (2) The celandine extract treated in (1) is combined, and the ethanol recovered under reduced pressure is concentrated to a relative density of 1.10;

[0029] (3) Use 1mol / L phosphoric acid to adjust the pH value to 3.4, refrigerate at 5°C for 48 hours, and then suction filter; adjust the pH value of the filtrate to 11 with 30% sodium hydroxide, extract 4 times with chloroform equivalent to the filtrate, and combine the chloroform Liquid, reclaim chloroform...

Embodiment example 3

[0035] Implementation case 3: a method for enriching and purifying chelidonine in celandine by using ultrasonic extraction-macroporous adsorption resin coupling method, the steps are as follows:

[0036] (1) After 500g of dried celandine is pulverized, cross 80 mesh sieves, extract with ultrasonic extraction, its concentration is 75% ethanol solution, the ratio of solid to liquid is 10 times of the crushed volume, the extraction temperature is 60°C, and the extraction frequency 100Hz, extraction time 2 hours, extraction 3 times;

[0037] (2) The celandine extract treated in (1) is combined, and the ethanol recovered under reduced pressure is concentrated to a relative density of 1.12;

[0038] (3) Use 1mol / L phosphoric acid to adjust the pH value to 3.5, refrigerate at 5°C for 48 hours, and then suction filter; adjust the pH value of the filtrate to 11 with 30% sodium hydroxide, extract 4 times with chloroform equivalent to the filtrate, and combine the chloroform Liquid, rec...

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Abstract

The invention belongs to the field of natural organic chemistry, and relates to a method for enriching and purifying chelidonine in celandine by using the ultrasonic extraction-macroporous adsorption resin coupling method. The method has the following advantages: as the ultrasonic extraction is adopted, the extraction effect is better than that of the ethanol hot-dipping extraction; the macroporous adsorption resin is combined, so that the adsorption selectivity to the chelidonine is good, the adsorption is fast, the analysis is fast, and the adsorption capacity is higher; the extraction is convenient and quick; the production cost is low; the separation effect is remarkable; the chelidonine semi-finished product with content above 30% and the chelidonine finished product with content above 90% can be obtained; and the defects of lower conventional extraction rate and low extraction purity are overcome. The method chooses the macroporous adsorption resin with stable physicochemical property, larger surface area, higher exchange speed, high mechanical strength, strong pollution resistance and good heat stability, can selectively adsorb the chelidonine from the solution through the physical adsorption, and has the advantages of quick adsorption, quick analysis and larger adsorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying chelidonine, in particular to a method for enriching and purifying chelidonine in chelidonium by using an ultrasonic extraction-macroporous adsorption resin coupling method. Background technique: [0002] Celandine: [English name] GreaterCelandineHerb, HerbofGreaterCelandine [alias] Dihuanglian, Niujinhua, Tuhuanglian, Babujin, Broken Heart Grass, Shanximelon, Realgargrass, Shanhuanglian, False Coptis, Xiaoyeren Xuecao, Huang Tangzi, Hu Huanglian, Xiaohuanglian. Medicinal base source: it is the whole herb of Papaveraceae celandine. Perennial herb, 30-100cm high, with orange latex. The main root is thick, conical, khaki or dark brown, and densely grown with fibrous roots. Stem erect, much branched, with white powder, with white slender pilose. Chemical composition: Fresh plants have a thick orange-yellow emulsion, which contains various alkaloids ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04
Inventor 祁佩时焦龙万莉姚德坤张亚红姚德利
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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