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Polysaccharide sulfate chewable tablet

A technology of bis-alginate sodium and chewable tablets, which can be used in pill delivery, metabolic diseases, digestive system, etc., and can solve problems such as low bioavailability and poor stability

Active Publication Date: 2013-05-08
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of poor stability and low bioavailability of the existing sodium alginate diester preparations, the present invention invented a liposome chewable tablet of sodium alginate diester inclusion compound, which achieved the purpose of high bioavailability and convenient administration

Method used

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  • Polysaccharide sulfate chewable tablet
  • Polysaccharide sulfate chewable tablet
  • Polysaccharide sulfate chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Liposome prescription:

[0045]

[0046]

[0047] Chewable Tablet Prescription:

[0048]

[0049] Preparation:

[0050] 1. Prepare sodium alginate diester inclusion compound according to the following method:

[0051] (1) In water or aqueous ethanol medium, react sodium alginate diester with hydroxypropyl β-cyclodextrin in proportion, filter the resulting solution through a microporous membrane until clear, and separate the clathrate from the mixture thing; or

[0052] (2) In solid form, react sodium alginate diester with hydroxypropyl β-cyclodextrin; or

[0053] (3) Sodium alginate diester reacts with hydroxypropyl β-cyclodextrin for high-energy grinding.

[0054] 2. prepare sodium alginate diester inclusion compound liposome according to the following method:

[0055] (1) Weigh soybean lecithin, phosphatidylglycerol, sodium taurocholate, cholesterol, methionine and butyl hydroxytoluene in proportion and dissolve them in absolute ethanol, and then inject ...

Embodiment 2

[0060] Liposome prescription:

[0061]

[0062] Chewable Tablet Prescription:

[0063]

[0064] The preparation method is the same as above.

Embodiment 3

[0066] Liposome prescription:

[0067]

[0068]

[0069] Chewable Tablet Prescription:

[0070]

[0071] The preparation method is the same as above.

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Abstract

The application relates to a chewable tablet, and particularly relates to a lipidosome chewable tablet containing polysaccharide sulfate clathrate compound.

Description

technical field [0001] The present application relates to a liposome chewable tablet, specifically, a liposome chewable tablet containing a sodium alginate diester inclusion complex. Background technique [0002] Liposomes (liposomes) were first proposed in 1965 by British banghan et al. as a model for studying biological membranes. Banghan et al. found that when phospholipids are dispersed in water, multilayer vesicles are formed, and each layer is a lipid bilayer , each layer is separated by a water phase. Later, this kind of closed vesicle composed of a lipid bilayer and an inner water phase is called a liposome. Since the structure of a sub-liposome is similar to a biological membrane, it is also called a liposome. Artificial biological membrane (artificalbiologicalmembrane). The size of liposome is from tens of nanometers (nanometres) to tens of microns (microns). Various substances can be wrapped in the aqueous phase and membrane of liposome. Lipid composed of natural ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/737A61K47/40A61P9/10A61P9/12A61P7/02A61P3/10A61P35/00A61P13/12A61P1/16A61P17/06A61P3/06
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD