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Compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution

A technology of composition and zinc cloth, which is applied in the direction of drug combination, metabolic disease, antiviral agent, etc., can solve the problems of not necessarily having high bioavailability, etc., and achieve the goal of overcoming and masking bitter taste, good taste, and improving dissolution rate Effect

Inactive Publication Date: 2013-05-15
HAINAN BRIGHT FUTURE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound zinc cloth granules that have been marketed in China do not have the test item for the dissolution of ibuprofen. Although this bitter taste can be masked, it does not necessarily have a high bioavailability in clinical practice.

Method used

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  • Compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution
  • Compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution
  • Compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution

Examples

Experimental program
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Effect test

Embodiment 1

[0114] Compound Zinc Cloth Granules

[0115] prescription:

[0116] Zinc Gluconate 100g

[0117] Ibuprofen 150g

[0118] Chlorpheniramine Maleate 2g

[0119] Sodium Lauryl Sulfate 0.45g

[0120] Vanillin 15g

[0121] Stevia 15g

[0122] Add sucrose to 3000g

[0123] Make 1000 bags

[0124] Its preparation method is:

[0125] 1) Preparation of wetting agent: Dissolve all the prescribed amount of chlorpheniramine maleate with an appropriate amount of purified water and set aside.

[0126] 2) Pass zinc gluconate, ibuprofen, and sucrose through a 60-mesh sieve respectively, and set aside.

[0127] 3) Weigh zinc gluconate, ibuprofen, sodium lauryl sulfate, stevia, vanillin and half of the amount according to the prescription

[0128] Mix the sucrose evenly, then add the remaining half of the sucrose and mix evenly.

[0129] 4) Add a wetting agent to make soft materials, pass through a 14-mesh sieve to make granules.

[0130] 5) The wet granules are dried at 50℃±5℃ unt...

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Abstract

The invention relates to the field of pharmaceutic preparation, and specifically relates to a compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution check item, and a preparation method thereof. The compound zinc gluconate and ibuprofen oral-administration composition for covering bitter taste and improving ibuprofen dissolution is characterized by mainly comprising main drugs: 0.036-0.83 of high-sweetness sugar, 5-15 of filler, and 0.0006-0.0060 of surfactant. The preparation provided by the invention is good in taste and high in bioavailability; and the composition is blended with water before administration so that the compliance of patients is improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound zinc cloth oral preparation for masking bitter taste and increasing ibuprofen dissolution test items and a preparation method thereof. Background technique [0002] Compound zinc cloth granule is an over-the-counter drug for cold medicine. Ibuprofen is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects. It is a prostaglandin inhibitor. Its curative effect and safety have been recognized by many scholars at home and abroad. COX can relieve the inflammatory reaction, fever and pain caused by the accumulation of prostaglandins, can significantly inhibit the metabolism of arachidonic enzymes to generate prostaglandin E (PGE), and can also inhibit tumor necrosis factor, interleukin-1, macrophages The release of inflammatory mediators such as inflammatory protein (MIP), thereby reducing the congestion and swelling of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K31/191A61K31/192A61K47/26A61K47/20A61P29/00A61P31/16A61P3/12
Inventor 廖锦红蒋万新符朝娜
Owner HAINAN BRIGHT FUTURE PHARMA