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Preparation method of highly-stable and cold water-soluble natural astaxanthin microcapsule preparation

A technology of natural astaxanthin and high stability, which is applied in the field of preparation of high-stability cold water-soluble natural astaxanthin microcapsule preparations, can solve problems such as poor transparency, and achieve the effect of improving stability

Active Publication Date: 2016-05-25
CHENGUANG BIOTECH GRP HANDAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method only uses shear emulsification, and does not use grinding or high-pressure homogenization to further reduce the particle size of the emulsion. The resulting product has poor transparency after being dispersed in water, and spray drying is only carried out for embedding once, and the stability needs to be further improved.

Method used

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  • Preparation method of highly-stable and cold water-soluble natural astaxanthin microcapsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Mix 30g of astaxanthin oil with a content of 10%, 3.0g of natural vitamin E, and 3.0g of polysorbate 80 at 55°C for 15 minutes until uniform to obtain an oil phase.

[0027] 2. Add 68g of gum arabic, 88g of sucrose, 4.0g of sodium ascorbate and 4.0g of tea polyphenols into 300g of purified water, stir at 75°C for 30 minutes until completely dissolved, adjust the pH value to 7.6, and obtain an aqueous phase.

[0028] 3. Add the oil phase at 55°C to the stirring water phase at 75°C, continue to stir for 30 minutes, then pass through the sand mill for 30 minutes, and the speed of the sand mill is 2200rpm, so that the particle size of the emulsion particles after grinding can reach 100nm Next, the obtained emulsion is granulated by spray cooling-starch fluidized bed drying method to obtain astaxanthin microcapsules. The spray drying conditions are: the inlet air temperature is 40°C, and the starch fluidized bed blast temperature is 65°C.

Embodiment 2

[0030] 1. Mix 300g of 10% astaxanthin oil, 60g of rosemary extract, and 30g of sucrose fatty acid ester at 55°C for 15 minutes until uniform to obtain an oil phase.

[0031] 2. Add 660g of sodium starch octenyl succinate, 900g of glucose, 25g of sodium ascorbate and 25g of tea polyphenol into 2.5kg of purified water, stir at 75°C for 30 minutes until completely dissolved, and adjust the pH to 7.8 to obtain an aqueous phase.

[0032] 3. Add the oil phase at 55°C to the stirring water phase at 75°C, continue to stir for 30 minutes, then pass through the sand mill for 30 minutes, and the speed of the sand mill is 2000rpm, so that the particle size of the emulsion particles after grinding can reach 100nm Next, the obtained emulsion is granulated by cold spray-starch fluidized bed drying method to obtain astaxanthin microcapsules. The spray drying conditions are: the inlet air temperature is 45°C, and the starch fluidized bed blast temperature is 60°C.

Embodiment 3

[0034] 1. Mix 6kg of astaxanthin oil with a content of 10%, 3kg of natural vitamin E, and 1.2kg of polyglycerol fatty acid ester at 55°C for 30 minutes until uniform to obtain an oil phase.

[0035] 2. Add 17.2kg of gum arabic, 12.0kg of isomalt, 0.3kg of sodium ascorbate and 0.3kg of citric acid into 40kg of purified water, stir at 75°C for 1 hour until completely dissolved, and adjust the pH value to 7.6 to obtain an aqueous phase.

[0036] 3. Add the oil phase at 55°C to the stirring water phase at 75°C, continue to stir for 30 minutes, then pass through the sand mill for 30 minutes, and the speed of the sand mill is 2100rpm, so that the particle size of the emulsion particles after grinding can reach 100nm Next, the obtained emulsion is granulated by cold spray-starch fluidized bed drying method to obtain astaxanthin microcapsules. The spray drying conditions are: the inlet air temperature is 40°C, and the starch fluidized bed blast temperature is 60°C.

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Abstract

The invention relates to a preparation method of a highly-stable and cold water-soluble natural astaxanthin microcapsule preparation. The method concretely comprises the following steps: uniformly mixing astaxanthin oil, an oil-soluble antioxidant and a water-soluble emulsifier under a heating condition to prepare an oil phase; adding a wall material, a water-soluble antioxidant and a filler to purified water, stirring and dissolving above added materials, and adjusting the pH value of the obtained solution to prepare a water phase; and adding the oil phase to the water phase, uniformly stirring the water phase and the oil phase, grinding the obtained mixture through a sand mill, and carrying out one-step granulation on the obtained emulsion through a cold spraying-starch fluidized bed drying technology to obtain the microcapsule preparation with the particle size of 40-100 meshes. The content reservation rate of the microcapsule preparation disposed at 40DEG C under RH of 75% for 6 months is greater than 95%, and 0.1g of the microcapsule preparation is dissolved in 100ml of water to form a clear, transparent and floating oil-free solution, so the microcapsule preparation can be applied in beverages and other aqueous foods.

Description

technical field [0001] The invention belongs to the carotenoid microcapsule technology, in particular to a preparation method of a highly stable cold water-soluble natural astaxanthin microcapsule preparation. Background technique [0002] Astaxanthin is a ketogenic non-provitamin A carotenoid. Because astaxanthin has various biological functions such as coloring, anti-oxidation, photoprotection, promotion of reproduction, enhancement of immunity, and maintenance of central nervous system health, it has attracted the attention of industries such as food, medicine, cosmetics, and aquaculture at home and abroad in recent years. Astaxanthin is mainly obtained through chemical synthesis and extraction from natural substances. The application of chemically synthesized astaxanthin is greatly limited due to its safety issues. Currently, among the biological sources of natural astaxanthin, Haematococcus pluvialis ( Haematococcus pluvialis ) has the highest content of astaxanthin,...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/122A61K47/36A61K8/35A61K8/11A61K8/73A23L33/00A23P10/30
Inventor 徐建中李新愿王红霞武亚明宋伟光
Owner CHENGUANG BIOTECH GRP HANDAN CO LTD
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