Fraxinus mandshurica extract for treating rheumatoid arthritis

A rheumatoid, extractive technology, applied in the fields of anti-inflammatory agents, food science, drug combination, etc., can solve the problem of less research on pharmacological activity, and achieve the effects of low toxicity, simple process and abundant resources

Inactive Publication Date: 2013-05-22
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

It has been reported in the literature that Fraxinus ash contains coumarin, phenylethanol glycosides, flavonoid...

Method used

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  • Fraxinus mandshurica extract for treating rheumatoid arthritis
  • Fraxinus mandshurica extract for treating rheumatoid arthritis
  • Fraxinus mandshurica extract for treating rheumatoid arthritis

Examples

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Embodiment 1

[0022] Preparation of Fraxinus Fraxinus Extract

[0023] Weigh 10kg of fresh leaves of Mandshurica mandshurica, mince them, add 90% ethanol, heat and reflux at 80°C for 3 times, each time for 1.5 hours, combine the extracts, recover ethanol under reduced pressure, and obtain extract A. Disperse the extract with 2L distilled water (30°C), extract 3 times with an equal volume of petroleum ether to remove low-polar compounds such as oil and chlorophyll, heat to remove the remaining petroleum ether, and put it on a Diaion HP-20 macroporous resin column , first eluted with distilled water until there was no sugar reaction, then eluted with 95% ethanol, and recovered ethanol under reduced pressure to obtain extract B. The extract B is separated with 200-300 mesh silica gel, firstly use ethyl acetate-methanol-water (volume ratio 8:2:0.5) to remove phenylethanol glycosides, and then use chloroform-methanol-water (volume ratio 8:2: 1 lower layer) to elute the coumarin glycosides, evap...

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Abstract

The invention discloses fraxinus mandshurica extract for treating rheumatoid arthritis and belongs to the technical field of traditional Chinese medicines. The fraxinus mandshurica extract comprises the following compounds in percentage by weight: 50%-95% of fraxinol glucoside, 2%-15% of fraxin, 0.1%-1% of isoscopolin and 0.1%-1% of isofraxidin-beta-D-glucoside. The fraxinus mandshurica extract has the beneficial effects of being low in toxicity, safe and reliable in comparison with chemical medicines such as hormones and the like while being applied to the medicine for treating rheumatoid arthritis; moreover, the fraxinus mandshurica leaf resources are abundant, the waste material is changed into things of value and the extraction process is simple; the fraxinus mandshurica extract and pharmaceutically acceptable excipients or auxiliaries materials can be used for preparing a medical composition; and the medical composition can be prepared into various dosage forms such as gastrointestinal tract dosage forms consisting of tablets, pills, capsules, particles, tinctures and oral liquid as well as gastrointestinal tract external dosage forms consisting of injections, external-use preparations and the like by adopting the conventional method of the galenic pharmacy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to the extraction of medicinal raw materials for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by joint synovitis. Synovitis is persistent and recurrent, which can lead to the destruction of cartilage and bone in the joint, joint dysfunction, and even disability. [0003] At the end of the last century, the prevalence rate of rheumatoid arthritis in foreign countries was 1% to 2%, higher than 5% in some regions, and about 0.3% to 0.45% in my country. There are more than 4 million people with arthritis. Patients with rheumatoid arthritis are getting younger. Zhang Hua from Neijiang City, Sichuan Province reported in 2010 that 65 children with rheumatoid arthritis had been treated in 3 years. Rheumatoid arthritis is not only a disease with a high disability rate, but also sho...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61K31/7048A61P19/02A61P29/00A23L1/29A23L33/00
Inventor 陈玉娟于源华王巍刘迪陈昆
Owner CHANGCHUN UNIV OF SCI & TECH
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