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Pellet preparation for normalizing stomach and tonifying spleen

A technology of pellets and preparations, which is applied in the field of pharmaceutical compositions and its preparation, and can solve problems such as unfavorable external development of traditional Chinese medicine preparations, single dosage form, and unfavorable drug safety for pediatric patients.

Active Publication Date: 2014-08-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used prescriptions for the treatment of children's anorexia mostly include Uncaria and cicada slough. side effects, which is also detrimental to the safety of the drug in pediatric patients
And in the prior art, dosage forms such as oral liquid and syrup are mostly used, and the dosage form is relatively single, which is not conducive to the external development of traditional Chinese medicine preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Magnolia officinalis 600g, chrysanthemum 600g, citrus aurantium 800g, coix seed 800g, rice bud 800g, hawthorn 400g, light bamboo leaf 600g, licorice 1000g, sucrose powder 800g, lactose amount, binder amount 70% ethanol amount.

[0023] The preparation method is as follows: 1) Weigh Magnolia officinalis officinalis officinale, chrysanthemum, Citrus aurantium, coix seed, hawthorn, rice bud, light bamboo leaf and licorice in parts by weight, soak, add 4 times of water and decoct 3 times, each time for 45 minutes, Combine the decoction liquid, concentrate, add 70% ethanol to stand still, filter, remove ethanol by rotary evaporation, and dry to obtain powder; 2) Take the powder prepared in 1), add lactose and mix evenly at a weight ratio of 1:0.3, and use an appropriate amount of 70% Ethanol is used as a binder to make soft materials. 3) By extrusion spheronization method, the extrusion speed is 30rpm, and the spheronization time is 5min to prepare pellets.

Embodiment 2

[0025] Magnolia officinalis 700g, chrysanthemum 700g, citrus aurantium 900g, coix seed 900g, rice bud 900g, hawthorn 500g, bamboo leaf 700g, licorice 1100g, sucrose powder 900g, appropriate amount of microcrystalline cellulose, and appropriate amount of binder HPMC solution.

[0026] The preparation method is as follows: 1) Weigh Magnolia officinalis officinalis officinale, chrysanthemum, Citrus aurantium, coix seed, hawthorn, rice bud, light bamboo leaf and licorice in parts by weight, soak, add 4 times of water and decoct 3 times, each time for 45 minutes, Combine the decoction liquid, concentrate, add 70% ethanol to stand still, filter, remove ethanol by rotary evaporation, and dry to obtain powder; 2) Take the powder prepared in 1), add microcrystalline cellulose in a weight ratio of 1:0.3 and mix well, use An appropriate amount of HPMC solution is used as a binder to make soft materials. 3) By extrusion spheronization method, the extrusion speed is 30rpm, and the spheroniz...

Embodiment 3

[0028] Magnolia officinalis 650g, chrysanthemum 650g, citrus aurantium 850g, coix seed 850g, rice bud 850g, hawthorn 450g, bamboo leaf 650g, licorice 1050g, sucrose powder 850g, appropriate amount of lactose, adhesive amount of 70% ethanol.

[0029] The preparation method is as follows: 1) Weigh Magnolia officinalis officinalis officinale, chrysanthemum, Citrus aurantium, coix seed, hawthorn, rice bud, light bamboo leaf and licorice in parts by weight, soak, add 4 times of water and decoct 3 times, each time for 45 minutes, Combine the decoction liquid, concentrate, add 70% ethanol to stand still, filter, remove ethanol by rotary evaporation, and dry to obtain powder; 2) Take the powder prepared in 1), add lactose and mix evenly at a weight ratio of 1:0.3, and use an appropriate amount of 70% Ethanol is used as a binder to make soft materials. 3) By extrusion spheronization method, the extrusion speed is 30rpm, and the spheronization time is 5min to prepare pellets.

[0030] ...

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PUM

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Abstract

The invention provides a pellet preparation for treating splenic and gastric incoordination and anorexia. The medicine comprises officinal magnolia bark, chrysanthemum, fructus aurantii, semen coicis, fructus oryzae germinatus, hawthorn, lophatherum gracile and liquorice; auxiliary materials, comprising a filler such as lactose, microcrystalline cellulose and amylum pregelatinisatum, an adhesive such as 70% ethanol or an HPMC (Hydroxy Propyl Methyl Cellulose) solution, and a corrigent which is sucrose powder, are added; and then pellet preparation is prepared by extrusion-spheronisaion.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a preparation of Hewei Jianpi pellets for treating anorexia and a preparation method thereof. Background technique [0002] Anorexia is the name of the disease in modern medicine, and its main clinical manifestations are loss of appetite and reduced food intake for a long time. Weak spleen and stomach, disharmony between spleen and stomach can cause anorexia, and the main clinical manifestations are loss of appetite and reduced food intake for a long time. According to the clinical manifestations of anorexia, Sang Li et al. divided them into six types: 1. Spleen dysfunction and movement type, which should be treated by invigorating the spleen to help transport, appetizing and increasing food; , 3. Liver Qi stagnation type, treatment should soothe liver and regulate qi, transport spleen and appetizer, 4. Food stagnation internal resistance type, tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K47/26A61K9/16A61P1/14
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD