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Traditional Chinese medicinal composition for treating lung cancer and liver cancer

A composition and anti-liver cancer technology, which can be applied in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., and can solve problems such as anti-hepatic and lung cancer effects that have not yet been discovered

Inactive Publication Date: 2013-06-12
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the patent of the pharmaceutical composition of saponins and astragalus polysaccharides (CN101152408A) has been reported, but no traditional Chinese medicine composition has been found that has the effect of anti-liver cancer and lung cancer and is composed of the extract of Chonglou and the extract of turmeric

Method used

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  • Traditional Chinese medicinal composition for treating lung cancer and liver cancer
  • Traditional Chinese medicinal composition for treating lung cancer and liver cancer
  • Traditional Chinese medicinal composition for treating lung cancer and liver cancer

Examples

Experimental program
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preparation example Construction

[0014] Preparation of Turmeric Extract:

[0015] Crush the turmeric medicinal material or decoction pieces into small pieces, soak 1g turmeric small pieces in 7ml of NaOH aqueous solution with a mass concentration of 1.3% in proportion, soak for 1 hour, reflux extraction at 90°C for 1 hour, filter, and press 1 Second reflux extraction operating conditions and then reflux extraction 2 times, filtered, combined 3 extracts, the filtrate was concentrated under reduced pressure to a relative density of 1.0 at 25°C, and the pH was adjusted to neutral with a hydrochloric acid-ethanol solution with a mass concentration of 1.7%. , adding absolute ethanol until the concentration of absolute ethanol accounts for 65% of the total volume, mixing, standing for 24 hours, filtering to obtain a precipitate, and freeze-drying the precipitate to obtain a turmeric extract.

Embodiment 1

[0017] A preparation of a traditional Chinese medicine composition for resisting liver cancer and lung cancer. According to the mass ratio, 1 part of Chonglou extract (specification 10:1) and 10 parts of turmeric extract are mixed evenly.

Embodiment 2

[0019] A preparation of a traditional Chinese medicine composition for resisting liver cancer and lung cancer. According to the mass ratio, 1 part of Chonglou extract (specification 20:1) and 5 parts of turmeric extract are mixed evenly.

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating lung cancer and liver cancer. The composition consists of rhizoma paridis yunnanensis extract and rhizoma curcumae longae extract according to a mass ratio of 1:(5-25). Experiments prove that the traditional Chinese medicinal composition can obviously inhibit lung cancer cell lines such as LA795 and hepatoma cell lines such as Hep-B3 from growing, the half maximal inhibitory concentrations (IC50) of the lung cancer cell lines and the hepatoma cell lines can respectively reach below 20 micrograms / milliliter; tests on mouse models bearing lung adenocarcinoma and liver cancer tumors show that the lung adenocarcinoma and liver cancer inhibition rates are respectively above 50%, and the spleen index and liver index of mice are increased; and compared with raw medicinal materials which are separately applied, the medicinal composition has high anti-lung cancer and anti-liver cancer activities, an exact effect and a good inhibition effect on lung cancer and liver cancer.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for resisting liver cancer and lung cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] The traditional Chinese medicine Chonglou is the dried rhizome of Paris polyphylla Smith var. It has the effect of relieving swelling and pain, cooling liver and relieving convulsions. It is used to treat boils, carbuncles, sore throat, poisonous snake bites, bruises, and convulsions caused by cool wind. Main constituent medicines such as tablets. Modern pharmacological studies have shown that Chonglou has cytotoxic activity, antibacterial and anti-inflammatory, analgesic, hemostatic, sedative, anti-early pregnancy, spermicidal, and effects on the respiratory system and cardiovascular system, etc. It is clinically used in the treatment of pulmonary diseases, functional Uterine hemorrhage, lymph node tuberculosis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P11/00A61P1/16A61P35/00
Inventor 高文远张瑶刘振满淑丽
Owner TIANJIN UNIV
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