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In vivo temperature measuring method and system based on alternating magnetization intensity of magnetic nanoparticles

A measurement method and technology of magnetization, applied in body temperature measurement, thermometers and thermometers using electric/magnetic elements that are directly sensitive to heat, can solve temperature measurement errors, difficulty in measuring the concentration distribution of magnetic nanoparticles, and no measurement scheme proposed And other issues

Inactive Publication Date: 2013-06-19
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

The particle size and saturation magnetic moment can be determined in advance through accurate and repeated tests in vitro, but the concentration distribution of magnetic nanoparticles in the body is difficult to measure, and no measurement scheme has been proposed so far
However, the uncertainty of the concentration distribution and spatial distribution of magnetic nanoparticles in the body will lead to great errors in temperature measurement in vivo. problem to be solved

Method used

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  • In vivo temperature measuring method and system based on alternating magnetization intensity of magnetic nanoparticles
  • In vivo temperature measuring method and system based on alternating magnetization intensity of magnetic nanoparticles
  • In vivo temperature measuring method and system based on alternating magnetization intensity of magnetic nanoparticles

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[0135] 1. Simulation model and test description:

[0136] In order to study the effectiveness and optimal design of the temperature test scheme, this example uses the simulation data containing noise to test the algorithm experimentally. The effective magnetic moment M of reagent particles used in the simulation test s measured as 4 x 10 -19 (Supplementary note that the measured value of the effective magnetic moment is determined by the reagent type parameter). Considering the error effect brought by the Fourier series quaternary approximation model of AC magnetization, it is necessary to use a weak AC excitation magnetic field amplitude. In this example, the AC excitation magnetic field amplitude H 0 = 100Oe. The noise model uses the awgn function in MATLAB to directly add the noise with a preset signal-to-noise ratio to the AC magnetization of the sampled signal. The signal-to-noise ratio included in the temperature measurement process is set to 80dB. According to diffe...

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Abstract

The invention discloses an in vivo temperature measuring method based on alternating magnetization intensity of magnetic nanoparticles and belongs to the technical field of nanometer testing. The method comprises the steps of putting a magnetic nanometer reagent at the position of a to-be-tested object, applying an alternating excitation field to an area of the magnetic nanometer reagent, collecting the alternating magnetization intensity of the magnetic nanometer reagent under action of the alternating excitation field, detecting all odd harmonic amplitudes in an alternating magnetization intensity signal, and finally calculating an in vivo temperature according to a relation of a harmonic and the temperature. The relation of all the odd harmonics and the in vivo temperature is preset through a discretization Langevin function and Fourier transform, and the in vivo temperature is solved through the relation without considering density information of the magnetic nanoparticles and variation, of effective magnetic moments, with the temperature during the solving process. Accurate detection of the in vivo temperature is achieved.

Description

technical field [0001] The invention relates to the technical field of nanometer testing, in particular to an in-body temperature measurement method and system based on the AC magnetization of magnetic nanoparticles. Background technique [0002] In vivo temperature refers to the temperature of tissues within an intact and living individual. In the field of biomedicine, in-body temperature measurement methods are divided into invasive measurement and non-invasive measurement. The invasive measurement method is simple, the measurement position is convenient for direct monitoring of the image, the measurement accuracy is high, and the temperature is measured in real time, but it causes greater trauma, and the insertion of the needle is easy to cause the transfer of diseased cells, and the radiation field of the heating source directly interacts with the probe. The decrease of measurement accuracy, the measured temperature data is point temperature, not the temperature field d...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/01
CPCA61B5/01A61B5/0515G01K7/36G01K13/20G06F17/16
Inventor 张朴钟景刘文中李寅何乐杜中州洪俊
Owner HUAZHONG UNIV OF SCI & TECH
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