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Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation

A phenophotosensitizer and nanomedicine technology, applied in the field of hydrophobic chlorin photosensitizer nanomedicine preparation and preparation, can solve problems such as rising cost, achieve the effects of simple structure, easy synthesis, and avoiding adverse clinical reactions

Inactive Publication Date: 2013-06-26
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are four hydroxyl groups on the molecule of temoporfin, which has good water solubility, but the hydroxyl groups need to be protected and deprotected during the synthesis process, which will cause an increase in the cost of drug synthesis

Method used

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  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation
  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation
  • Hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation based on albumin as well as preparation method and application of nanometer pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation and application of a nano-medicine preparation based on human serum albumin-based photosensitizer:

[0041] Dissolve human serum albumin in water to form an aqueous solution of 10 mg / ml human serum albumin.

[0042] The photosensitizer meta-tetraphenylchlorin was dissolved in tetrahydrofuran to form a photosensitizer solution of 1 mg / ml.

[0043] During the stirring process, 10 ml of photosensitizer solution (1 mg / ml) was added dropwise to 50 ml of human serum albumin solution (10 mg / ml) to obtain a mixed solution.

[0044] Centrifuge the mixed solution (13000 rpm) to remove the precipitate and collect the supernatant.

[0045] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was filtered and sterilized with a 0.22 micron filter membrane. Concentrate to obtain a human serum albumin-photosensitizer nano drug solution.

[0046] Add the human serum albumin-based photosensitizer nanomedicine solution to the...

Embodiment 2

[0048] Preparation and application of a nano-pharmaceutical preparation based on human serum albumin-based photosensitizer:

[0049] Dissolve human serum albumin in water to form an aqueous solution of human serum albumin of 5 mg / ml.

[0050] The photosensitizer meta-tetraphenylchlorin was dissolved in tetrahydrofuran to form a photosensitizer solution of 1 mg / ml.

[0051] During the stirring process, 12 ml of photosensitizer solution (1 mg / ml) was added dropwise to 50 ml of human serum albumin solution (5 mg / ml) to obtain a mixed solution.

[0052] Centrifuge the mixed solution (14800 rpm) to remove the precipitate and collect the supernatant.

[0053] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was filtered and sterilized with a 0.22 micron filter membrane. Concentrate to obtain a human serum albumin-photosensitizer nano drug solution.

[0054] Add the human serum albumin-based photosensitizer nanomedicine solution...

Embodiment 3

[0056] Preparation of a nano-pharmaceutical preparation of photosensitizer based on human serum albumin:

[0057] Dissolve human serum albumin in water to form an aqueous solution of human serum albumin of 5 mg / ml.

[0058] The photosensitizer meta-tetraphenylchlorin was dissolved in ethanol to form a photosensitizer solution of 0.2 mg / ml.

[0059] During the stirring process, 15 ml of photosensitizer solution (0.2 mg / ml) was added dropwise to 50 ml of human serum albumin solution (5 mg / ml) to obtain a mixed solution.

[0060] Centrifuge the mixed solution (14800 rpm) to remove the precipitate and collect the supernatant.

[0061] The obtained supernatant was dialyzed to obtain a photosensitizer nano drug solution of human serum albumin, which was filtered and sterilized with a 0.22 micron filter membrane. Concentrate to obtain a human serum albumin-photosensitizer nano drug solution.

[0062] The human serum albumin-based photosensitizer nanomedicine solution was injected through the t...

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Abstract

The invention discloses a hydrophobic dihydroporphin photosensitizer nanometer pharmaceutic preparation. The preparation is only composed of albumin and hydrophobic dihydroporphin photosensitizer and is free of other cross-linking agents or auxiliary materials. The used hydrophobic dihydroporphin photosensitizer is simple in structure, free of hydroxyl, alkoxyl, amino group and the like, capable of improving water-soluble functional groups of the dihydroporphin photosensitizer and easy to synthesize. The invention further discloses a preparation method and application of the nanometer medicine pharmaceutic preparation.

Description

Technical field [0001] The invention relates to a nano pharmaceutical preparation, in particular to an albumin-based hydrophobic chlorin photosensitizer nano pharmaceutical preparation, a preparation method and an application thereof. Background technique [0002] Serum albumin is widely distributed in the blood. Serum albumin is a protein with the largest content, smallest molecule, high solubility, and more functions in plasma. Due to its degradability, serum albumin is considered a potential and safe drug carrier. Since albumin contains amino, carboxyl and sulfhydryl functional groups, previous research was to obtain albumin nanoparticles by introducing a cross-linking agent, and further load chemotherapeutic drugs and hydrophilic chlorin derivatives on the albumin nanoparticles Molecules, it is expected to improve the distribution of drugs at the lesion site (US2006 / 0234960A1; US2011 / 0142948A1; US2011 / 0275686A1; CN101569609A; CN1736489A). [0003] In 1976, the clinical appli...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/42A61K9/19A61K9/14A61P35/00
Inventor 张晓宏安菲菲
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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