Establishing method of hypertensive disorder complicating pregnancy mouse model

Abstract

The invention discloses an establishing method of a hypertensive disorder complicating pregnancy mouse model. The establishing method of the hypertensive disorder complicating pregnancy mouse model comprises the following steps of: extracting a syncytiotrophoblast microvilli membrane; and inputting the syncytiotrophoblast microvilli membrane to a pregnant mouse body of the same strain by caudal vein injection to establish the hypertensive disorder complicating pregnancy mouse model. The hypertensive disorder complicating pregnancy mouse model established by the establishing method disclosed by the invention has hypertensive disorder complicating pregnancy characteristic symptoms and signs including elevation of blood pressure, eclampsia hyperspasmia, damages to heart and liver and the like, which are consistent with the symptoms and pathological process of the hypertensive disorder complicating pregnancy including eclampsia and the like at the early stage of the human eclampsia, and therefore, the hypertensive disorder complicating pregnancy mouse model can be used for researching the occurrence and development mechanism of the hypertensive disorder complicating pregnancy including eclampsia and the like at the early stage of the eclampsia, as well as the medical foundation with the purpose of developing antagonistic medicaments and the clinical research.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a method for establishing a mouse model of hypertensive disorder during pregnancy. Background technique [0002] Hypertensive disorders of pregnancy represented by preeclampsia (PE) and eclampsia (eclampsia) are important obstetric diseases that seriously threaten the health of pregnant women and fetuses, and their pathogenesis is still unknown. Syncytiotrophoblast microvillous membrane (STBM) in maternal blood circulation is considered to be an important factor in the pathogenesis of preeclampsia and eclampsia because it can act on peripheral blood vessels and cause vascular endothelial cell dysfunction. [0003] Based on the ethical requirements of medical research and the special nature of the pregnancy process, it is currently impossible to study the specific role and mechanism of syncytiotrophoblast microchorion in human hypertensive disorders of pregnancy through clinical trials....

AI Technical Summary

Problems solved by technology

[0003] Based on the ethical requirements of medical research and the special nature of the pregnancy process, it is currently impossible to study the specific role and mechanism of syncytiotrophoblast microchorion in human hypertensive disorders during pregnancy through clinical trials

At the same time, since there is no animal model with syncytiotrophoblast microchorion as the research target, corresponding animal experiments and in vivo studies cannot be carried out.

This limits further research on hypertensive disorders of pregnancy such as preeclampsia and eclampsia

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