Use of palchouli oil in preparation of antiviral drug

An antiviral drug, the technology of Agaricus oil, applied in antiviral agents, food science, pharmaceutical formulations, etc., can solve the problem of unclear anti-influenza virus effect, virus drug resistance, and exact curative effect, etc. To achieve the effect of significant inhibitory effect, exact curative effect and good clinical application prospect

Inactive Publication Date: 2013-07-10
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the 1990s, researchers have discovered many new antiviral drugs. At present, more than 20 antiviral drugs have been used clinically, but their exact efficacy is still controversial, and antiviral chemically synthesized drugs have long been used. After application, the virus easily develops drug resistance to it, which has become a thorny problem in the clinical treatment of viral diseases
Modern pharmacology shows that Patchouli has anti-pathogenic microorganisms, anti-inflammatory, antipyretic, and analgesic effects. The material basis is not yet clear and there is no report of its anti-influenza virus effect in vivo

Method used

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  • Use of palchouli oil in preparation of antiviral drug
  • Use of palchouli oil in preparation of antiviral drug
  • Use of palchouli oil in preparation of antiviral drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Huoxiang oil of the present invention

[0024] Take the whole herb of Pogostemon cablin (Blanco) Benth., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak it for 1-5 hours, and extract it by steam distillation for 2-6 hours, that is Get Patchouli Oil of the present invention, also known as Patchouli Oil, wherein, containing Pocketberry Alcohol (C 15 h 26 O) must not be lower than 40% w / w and patchoulone must not be lower than 20% w / w.

Embodiment 2

[0025] The preparation of embodiment 2 Huoxiang oil of the present invention

[0026] Take the whole herb of Agastache rugosa (Fisch.Et Mey.) O.Ktze., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak for 1-5 hours, and extract 2 by steam distillation. -6 hours, to obtain Huoxiang oil of the present invention.

[0027] Huoxiang oil of the present invention also can extract according to Pharmacopoeia (2005 edition) appendix XD volatile oil determination method, also can adopt organic solvent extraction, supercritical CO 2 extraction and other existing techniques, or obtain by purchasing commercially available products.

[0028] Prove the beneficial effects of the present invention below by drug efficacy test:

experiment example 1

[0029] Experimental example 1 antiviral experiment of Huoxiang oil of the present invention in vitro

[0030] 1. Materials and instruments

[0031] 1.1 Cell strains and virus strains

[0032] 1.1.1 Cell lines:

[0033] MDCK cells (canine kidney cells), Hep-2 cells (human laryngeal carcinoma epithelial cells), and HeLa cells (cervical cancer cells) were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0034] 1.1.2 Virus strains:

[0035]The A / PR / 8 / 34 strain of influenza A virus with serotype H1N1 (hereinafter referred to as influenza virus) was selected from the National Influenza Center; From the Sichuan Provincial Clinical Inspection Center; adenovirus type 3 (Ad-3) was selected as a gift from the Gansu Provincial Center for Disease Control and Prevention.

[0036] 1.2 Drugs and control drugs

[0037] Test drug: invented drug: patchouli oil prepared in Example 1.

[0038] Positive drug: ribavirin injection: the specifi...

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PUM

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Abstract

The invention discloses use of palchouli oil in preparation of an antiviral drug, and discloses an antiviral pharmaceutical composition, which is a drug prepared from the palchouli oil as an active ingredient and a pharmaceutically acceptable auxiliary material or an auxiliary ingredient. The palchouli oil disclosed by the invention is significant in anti-virus effect, can treat a disease caused by virus, is accurate in curative effect on vital myocarditis and pneumonia, and has strong practical application value.

Description

technical field [0001] The present invention relates to the new application of Huoxiang oil, in particular to the application of Huoxiang oil in preparing antiviral medicine. Background technique [0002] Infectious diseases caused by viruses have been a serious threat to human life and health. According to statistics, more than 80% of infectious diseases are caused by viruses. Viral diseases have been involved in various fields of clinical medicine. At present, viruses and the diseases caused by them have become the focus of many disciplines. The most common viral infectious diseases are those caused by respiratory viruses and enteroviruses. [0003] Respiratory viruses are a large class of viruses that can invade the respiratory tract and cause local lesions of the respiratory tract, or viruses that only use the respiratory tract as an invasion portal to cause lesions of respiratory tract tissues and organs. They are the main pathogens that cause acute respiratory infecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61P31/16A61P31/12A61P31/14A23L33/00
CPCA61K36/53A61P31/12A61P31/14A61P31/16A61P31/20
Inventor 彭成魏晓露万峰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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