Use of palchouli oil in preparation of antiviral drug
An antiviral drug, the technology of Agaricus oil, applied in antiviral agents, food science, pharmaceutical formulations, etc., can solve the problem of unclear anti-influenza virus effect, virus drug resistance, and exact curative effect, etc. To achieve the effect of significant inhibitory effect, exact curative effect and good clinical application prospect
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Embodiment 1
[0023] The preparation of embodiment 1 Huoxiang oil of the present invention
[0024] Take the whole herb of Pogostemon cablin (Blanco) Benth., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak it for 1-5 hours, and extract it by steam distillation for 2-6 hours, that is Get Patchouli Oil of the present invention, also known as Patchouli Oil, wherein, containing Pocketberry Alcohol (C 15 h 26 O) must not be lower than 40% w / w and patchoulone must not be lower than 20% w / w.
Embodiment 2
[0025] The preparation of embodiment 2 Huoxiang oil of the present invention
[0026] Take the whole herb of Agastache rugosa (Fisch.Et Mey.) O.Ktze., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak for 1-5 hours, and extract 2 by steam distillation. -6 hours, to obtain Huoxiang oil of the present invention.
[0027] Huoxiang oil of the present invention also can extract according to Pharmacopoeia (2005 edition) appendix XD volatile oil determination method, also can adopt organic solvent extraction, supercritical CO 2 extraction and other existing techniques, or obtain by purchasing commercially available products.
[0028] Prove the beneficial effects of the present invention below by drug efficacy test:
experiment example 1
[0029] Experimental example 1 antiviral experiment of Huoxiang oil of the present invention in vitro
[0030] 1. Materials and instruments
[0031] 1.1 Cell strains and virus strains
[0032] 1.1.1 Cell lines:
[0033] MDCK cells (canine kidney cells), Hep-2 cells (human laryngeal carcinoma epithelial cells), and HeLa cells (cervical cancer cells) were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.
[0034] 1.1.2 Virus strains:
[0035]The A / PR / 8 / 34 strain of influenza A virus with serotype H1N1 (hereinafter referred to as influenza virus) was selected from the National Influenza Center; From the Sichuan Provincial Clinical Inspection Center; adenovirus type 3 (Ad-3) was selected as a gift from the Gansu Provincial Center for Disease Control and Prevention.
[0036] 1.2 Drugs and control drugs
[0037] Test drug: invented drug: patchouli oil prepared in Example 1.
[0038] Positive drug: ribavirin injection: the specifi...
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