Liposome Extrusion Filtration Device

A filter device and liposome technology, applied in the direction of filtration separation, fixed filter element filter, semi-permeable membrane separation, etc., can solve the problems of cross contamination, inconvenient maintenance, troublesome use and operation, etc., and achieve convenient use and maintenance, and realize Precise control to avoid cross-contamination effects

Active Publication Date: 2015-09-02
安拓思纳米技术(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing high-pressure homogenizer and extrusion filter are separated, which will cause cross-contamination, and troublesome operation and maintenance

Method used

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  • Liposome Extrusion Filtration Device
  • Liposome Extrusion Filtration Device
  • Liposome Extrusion Filtration Device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 , Liposome extrusion filter device

[0021] Such as Figure 1 to Figure 5 A kind of liposome extruding filtration device 13 shown, comprises: discharge pipe 1, loam cake 2, extrude outer gasket 3, support plate 4, filter plate 5, filter membrane 6, extrude inner gasket 7 , joint 8, valve body gasket 9, clamp 10, clamp locking bolt 11 and valve body seal groove 12, the valve body seal groove 12 is arranged on the outer edge of the lower end of the joint 8, and the valve body seal The gasket 9 is arranged inside the sealing groove 12 outside the valve body, and the center of the joint 8 is provided with a feed through hole; the center of the upper cover 2 is provided with a discharge through hole, and the center of the discharge through hole The upper opening is connected to the discharge pipe 1, and the bottom surface of the upper cover 2 is provided with an indented cylindrical groove and an annular sealing groove, and the annular sealing groove is located ...

Embodiment 2

[0022] Example 2 , Liposome extrusion filter device

[0023] Such as Figure 1 to Figure 5 A kind of liposome extruding filtering device 13 shown, comprises: discharge pipe 1, loam cake 2, extruding outer gasket 3, support plate 4, filter plate 5, polycarbonate filter membrane 6, extruding inner Sealing gasket 7, joint 8, sealing gasket 9 outside the valve body, clamp 10, clamp locking bolt 11 and sealing groove 12 outside the valve body, the sealing groove 12 outside the valve body is arranged on the outer edge of the lower end of the joint 8, the The sealing gasket 9 outside the valve body is arranged inside the sealing groove 12 outside the valve body, and the center of the joint 8 is provided with a feed through hole; the center of the upper cover 2 is provided with a discharge through hole, and the discharge The upper opening of the through hole is connected to the discharge pipe 1, and the bottom surface of the upper cover 2 is provided with an indented cylindrical gr...

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Abstract

The invention provides a lipidosome extruding and filtering device which comprises a material discharge pipe, an upper cover, an extruding outer seal gasket, a support plate, a filtering plate, a filtering membrane, an extruding inner seal gasket, a connector, a hoop and a hoop locking bolt; the center of the connector is provided with a material charge through hole; the center of the upper cover is provided a material discharge through hole of which the opening at the upper end is connected with the material discharge pipe; the bottom surface of the upper cover is provided with an annular seal groove and an internally sinking cylindrical groove; the support plate, the filtering plate, the filtering membrane and the extruding inner seal gasket are sequentially arranged in the cylindrical groove from inward to outward; the extruding outer seal gasket is arranged in the annular seal groove; the upper cover and the connector are fixed together through the hoop and the hoop locking bolt. According to the invention, nanocrystallized equipment and homogenized equipment are designed integrally; material particle size can be controlled accurately through replacing different filtering membranes; cross contamination is prevented; and the lipidosome extruding and filtering device is convenient to use, and can be widely applied to the nano medicament field.

Description

technical field [0001] The invention relates to a high-pressure filter device, in particular to a liposome extrusion filter device. Background technique [0002] When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure , called liposomes, ranging from 25 to 1000 nm in diameter. Liposome is a targeted drug carrier, which belongs to a new dosage form of targeted drug delivery system. It can embed drug powder or solution in nanometer-sized particles, which have a cell-like structure, enter the human body and be swallowed by the reticuloendothelial system to activate the body's autoimmune function and change the encapsulated drug The distribution in the body makes the drug mainly accumulate in tissues and organs such as liver, splee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D29/05B01D61/00
Inventor 童舸嵇洪将
Owner 安拓思纳米技术(苏州)有限公司
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