Cefpodoxime proxetil composition dry suspension and preparation method thereof

A technology of cefpodoxime axetil and dry suspension, which is applied in the field of medicine, can solve problems such as unfavorable swallowing, poor dissolution rate, and poor compliance of patients to take, and achieve drug agglomeration, high dissolution rate, stability and safety small effect

Active Publication Date: 2014-11-12
SHANDONG LUOXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, most of the cefpodoxime axetil preparations are tablets, which are not conducive to swallowing, and the dissolution rate is poor, resulting in poor patient compliance

Method used

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  • Cefpodoxime proxetil composition dry suspension and preparation method thereof
  • Cefpodoxime proxetil composition dry suspension and preparation method thereof
  • Cefpodoxime proxetil composition dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 cefpodoxime axetil composition dry suspension

[0035]

[0036] Take cefpodoxime axetil and sucrose to pass through a 100-mesh sieve, add mannitol and mix, add starch slurry to make soft material, pass through a 40-mesh sieve to granulate, then dry at 45-50°C for 25-30 minutes, and pass through a 40-mesh sieve Serve whole grains.

Embodiment 2

[0037] The preparation of embodiment 2 cefpodoxime axetil composition dry suspension

[0038]

[0039] Take cefpodoxime axetil and sucrose to pass through a 100-mesh sieve, add mannitol and mix, add starch slurry to make soft material, pass through a 40-mesh sieve to granulate, then dry at 45-50°C for 25-30 minutes, and pass through a 40-mesh sieve Serve whole grains.

Embodiment 3

[0040] The preparation of embodiment 3 cefpodoxime axetil composition dry suspension

[0041]

[0042] Take cefpodoxime axetil and sucrose to pass through a 100-mesh sieve, add mannitol and mix, add starch slurry to make soft material, pass through a 40-mesh sieve to granulate, then dry at 45-50°C for 25-30 minutes, and pass through a 40-mesh sieve Serve whole grains.

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PUM

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Abstract

The invention relates to the technical field of medicines and in particular relates to a cefpodoxime proxetil composition dry suspension and a preparation method thereof. The cefpodoxime proxetil composition dry suspension comprises the following materials: cefpodoxime proxetil, sucrose, mannitol and starch slurry. Through the combined action of sucrose, mannitol and starch slurry, the cefpodoxime proxetil composition dry suspension, which is high in dissolution rate, stronger in antibacterial action and good in stability, is obtained on the condition that the process of adding suspending aid is omitted. Moreover, the prepared cefpodoxime proxetil composition dry suspension can be used for preventing medicines from packing and further can be used for strengthening the antibacterial action of the cefpodoxime proxetil.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a dry suspension of cefpodoxime axetil composition and a preparation method thereof. Background technique [0002] Antimicrobial infection drugs are the second largest class of drugs in the global pharmaceutical market today, and β-lactam antibiotics are the most clinically used, most widely used, most diverse, best curative effect and highest evaluation class Antibiotics play an important role in anti-infective drugs, accounting for 58.7% of the total global sales of antibiotics. Among them, cephalosporin series products account for about 70%. It can be seen that in the pharmaceutical market, cephalosporins occupy an important position in β-lactam antibiotics and even anti-infective drugs. [0003] Among various cephalosporins, oral cephalosporins are popular among medical staff and patients because of their convenience and cost-effectiveness. In 1990, the output of cephalosp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/26A61K47/10A61K47/36A61K31/546A61P31/04
Inventor 侯善波冯长银蒋燕杰
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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