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Inactivated vaccine producing and using method

An inactivated vaccine and inactivation technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, virus antigen components, etc., can solve the problems of non-freezing and short validity period, and achieve no fear of freezing, long validity period, and labor saving Effect

Inactive Publication Date: 2013-08-07
施庆才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the shortcomings of liquid inactivated vaccines that need to be stored and transported at 2-8°C, cannot be frozen, have a short validity period, contain a certain amount of preservatives (thimerosal), and have potential food safety risks, etc.

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0007] The specific examples of the present invention are described below, and it should be noted that the examples are only illustrative of the present invention, not limiting.

[0008] Implementing method of chicken Newcastle disease inactivated vaccine

[0009] 1. Obtain chicken Newcastle disease virus liquid by conventional methods.

[0010] 2. Use ultrafiltration concentration technology to carry out multiple concentration of virus liquid (high titer can not be concentrated), add 10% formaldehyde solution, make it fully mixed, the final concentration of formaldehyde solution is 0.1%. Heat to 37°C for inactivation, start counting when the temperature in the tank reaches 37°C, and inactivate for 16 hours.

[0011] 3. Add 5% sucrose milk protectant to the qualified inactivated solution at a ratio of 1:1, mix thoroughly, then quantitatively dispense and freeze-dry in a vacuum to make a dry powdered inactivated vaccine.

[0012] 4. Two usage methods:

[0013] 1) Dilute with...

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PUM

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Abstract

The invention provides an inactivated vaccine producing and using method. The inactivated vaccine produced by the method does not contain thiomersalate, can be stored and transported in a common environment, can not be frozen and is long in validity period. Multiple varieties can be combined and used, one-step inoculation is realized, and lots of manual labor is saved. By adoption of the technical scheme, the inactivated antigen is manufactured into dry powder inactivated antigen by adopting the freeze vacuum drying technology or other drying technologies, and the inactivated vaccine is diluted by using a proper amount of diluent during use or can be used after being emulsified by a proper amount of adjuvant.

Description

technical field [0001] The invention relates to a method for producing and using an inactivated vaccine, belonging to the field of veterinary biological products. Background technique [0002] At present, most of the inactivated vaccines, such as avian influenza inactivated vaccine, chicken Newcastle disease inactivated vaccine, chicken infectious bursal disease inactivated vaccine, egg production drop syndrome inactivated vaccine, chicken infectious bronchitis inactivated vaccine, chicken virus Inactivated arthritis vaccine, pseudorabies inactivated vaccine, foot-and-mouth disease inactivated vaccine, porcine encephalitis Japanese encephalitis inactivated vaccine, porcine circular disease inactivated vaccine, porcine blue ear disease inactivated vaccine, etc. are all liquid vaccines. The specific method is to emulsify the inactivated antigen with a suitable adjuvant to form an oil emulsion liquid inactivated vaccine, and use it directly when in use. Liquid inactivated vacc...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K39/00A61K39/17
Inventor 施庆才
Owner 施庆才