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Celecoxib effervescent tablet and preparation method thereof

A technology for celecoxib and effervescent tablets, applied in the field of celecoxib effervescent tablets and their preparation, can solve the problems of affecting the therapeutic effect of celecoxib, long disintegration time of ordinary tablets, large proportion of auxiliary materials, etc. problems, to achieve the effect of improving medication compliance, convenience in taking, and rapid absorption

Active Publication Date: 2015-12-09
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Ordinary tablets of celecoxib take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of celecoxib. to play

Method used

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  • Celecoxib effervescent tablet and preparation method thereof
  • Celecoxib effervescent tablet and preparation method thereof
  • Celecoxib effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0034] prescription:

[0035]

[0036] Preparation:

[0037] (1) the celecoxib powder (200 meshes) and the sucrose powder (150 meshes) are uniformly mixed in an equal amount in an incremental manner to obtain mixture A;

[0038] (2) after passing the remaining auxiliary materials through a 200-mesh sieve, the mixture is uniformly mixed in an equal increment to obtain mixture B;

[0039] (3) Mix the mixture A and the mixture B uniformly by the equal increment method, and then directly press the tablet.

Embodiment 2

[0041] prescription:

[0042]

[0043] Preparation:

[0044] (1) mixing celecoxib powder (200 meshes) and lactose powder (150 meshes) in equal amounts in an incremental manner to obtain mixture A;

[0045] (2) after passing the remaining auxiliary materials through a 200-mesh sieve, the mixture is uniformly mixed in an equal increment to obtain mixture B;

[0046] (3) Mix the mixture A and the mixture B uniformly by the equal increment method, and then directly press the tablet.

Embodiment 3

[0048] prescription:

[0049]

[0050]

[0051] Preparation:

[0052] (1) mixing celecoxib powder (200 meshes) and lactose powder (150 meshes) in equal amounts in an incremental manner to obtain mixture A;

[0053] (2) after passing the remaining auxiliary materials through a 200-mesh sieve, the mixture is uniformly mixed in an equal increment to obtain mixture B;

[0054] (3) Mix the mixture A and the mixture B uniformly by the equal increment method, and then directly press the tablet.

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PUM

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Abstract

The invention discloses celecoxib effervescent tablets which are used for treating rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The tablets can also be used for treating acute pain, dysmenorrhea, colorectal polyps and post-operative analgesia, lower back pain, shoulder periarthritis and tenosynovitis. According to the invention, celecoxib is adopted as a raw material, and auxiliary materials are added, such that the celecoxib effervescent tablets are prepared. The celecoxib effervescent tablets have the advantages of fast disintegration, fast absorption high bioavailability, convenient application, low intestinal residue, low side effect, and sweet taste and good fragrance. With the tablets and the method, patient medication compliance can easily be improved.

Description

technical field [0001] The invention relates to a new dosage form of celecoxib, in particular to a celecoxib effervescent tablet and a preparation method thereof. Background technique [0002] Celecoxib is a blockbuster drug developed and sold by Pfizer, mainly for the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, but also for the treatment of acute pain, dysmenorrhea, colorectal polyps and post-operative sedation. Pain etc. Celecoxib was approved for lower back pain, frozen shoulder, and tenosynovitis in 2007. Celecoxib is in Phase III clinical trials for traumatic pain and post-dental pain, and is also being studied for the treatment of various tumors including breast, lung, and pancreatic cancer. The latest epidemiological, clinical and experimental studies at home and abroad show that celecoxib also has the effect of preventing and inhibiting tumors. Due to its strong targeting and small side effects, it has played an important role in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K31/415A61K47/46A61P29/00A61P19/02A61P19/08A61P1/00A61P35/00
Inventor 王超志
Owner GUIZHOU LIANSHENG PHARMA
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