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Sutureless ureterostenosis restoration operation material and system thereof

A technology for ureteral stenosis, which is applied in the field of materials and systems for repairing ureteral stenosis, can solve the problems of high incidence of restenosis and many side effects, and achieve the effect of reducing the occurrence rate, restenosis, and pain of patients

Inactive Publication Date: 2013-08-14
NO 3 PEOPLE HOSPITAL AFFILIATED TO SHANGHAI JIAOTOG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems of excessive side effects and high incidence of restenosis in the traditional surgery for repairing ureteral stenosis, the present invention provides a suture-free surgical material for repairing ureteral stenosis, its preparation method and system, and rose red Application of suturing materials in repairing ureteral stricture

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Use poly-L-lactic acid as the rose red carrying material, area (1.5x2)cm 2 , dipped in 0.07% rose bengal solution for more than 5min, and kept away from light for later use.

[0040] After resection of the ureteral stenosis, a flexible tube was implanted, the ends were closed, and poly-L-lactic acid with rose red was wrapped on the joint. The 532nm laser emitting device irradiated the local area for 5 minutes and 40 seconds, and the parameters were set at 0.3W / cm 2 .

[0041] The anastomosis is completed and the operation is over.

[0042] After rose bengal is used on the wound, the internal conformation of rose bengal molecules will change after being activated by laser light, so that rose bengal will change into an excited state and an unstable state. When these unstable excited state molecules meet the collagen molecules in the tissue, electron transfer occurs between the excited state rose bengal and the collagen molecules, forming collagen molecules with positi...

Embodiment 2

[0045] Amniotic membrane is used as rose red carrying material, area (1.5x2)cm 2 , dipped in 0.1% rose bengal solution for more than 3min, and kept away from light for later use.

[0046] After resection of the ureteral stenosis, a flexible tube was implanted, the ends were closed, and the amniotic membrane with rose red was wrapped on the joint. The 532nm laser emitting device irradiated the local area for 3 minutes and 20 seconds, and the parameter was set at 0.4W / cm 2 .

[0047] The anastomosis is completed and the operation is over.

Embodiment 3

[0049] Polycaprolactone / collagen / lactic acid / glycolic acid copolymer / dextran blend as rose red carrying material, area (1.5x2)cm 2 , dipped in 0.15% rose bengal solution for more than 3.5min, and kept away from light for later use.

[0050] After resection of the ureteral stricture, a flexible tube was implanted, and the stump was apposed, and the apposition was wrapped with rose red polycaprolactone / collagen / lactic acid / glycolic acid copolymer / dextran blend, 532nm The laser emitting device performs local laser irradiation for 4 minutes, and the setting parameter is 0.5W / cm 2 .

[0051] The anastomosis is completed and the operation is over.

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PUM

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Abstract

The invention provides a sutureless ureterostenosis restoration operation material, a preparation method of the material, a sutureless ureterostenosis restoration operation system including the material, and applications of rose bengal in the material and the system. Rose Bengal is supported on a rose bengal support, and a sutureless ureterostenosis restoration operation is completed through the local irradiation of a laser emission device. Results of clinic tests show that ureteral restenoses erupting after a traditional suture operation are not found, and there are also no tissue thermal damage phenomena.

Description

technical field [0001] The invention relates to a material for repairing ureteral stenosis, in particular to a material and a system for repairing ureteral stenosis without sutures and effectively avoiding restenosis of the ureter. Background technique [0002] Ureteral stenosis refers to the narrow caliber of the ureter, which affects urine excretion. Ureteral stenosis is one of the most difficult clinical problems to deal with. Stenosis causes upper urinary tract obstruction, hydronephrosis, and then kidney failure, which seriously affects the health and life of patients. Generally, ureteral stenosis is divided into two categories: 1. Congenital ureteral stenosis; 2. Secondary ureteral stenosis. The common causes are congenital ureteropelvic junction stenosis, ureterolithiasis, inflammation and other long-term lesions or stenosis caused by surgery. [0003] The current treatment methods for ureteral strictures are mainly surgical incision and plastic surgery or non-surgica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06
Inventor 姚敏倪涛王莹方勇
Owner NO 3 PEOPLE HOSPITAL AFFILIATED TO SHANGHAI JIAOTOG UNIV SCHOOL OF MEDICINE
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