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Pharmaceutical composition for treating diabetic feet caused by diabetes and acro-skin lesion and preparation method of pharmaceutical composition

A technology for diabetic foot and skin lesions, applied in the field of pharmaceutical compositions and their preparation, can solve the problems of difficult healing of surgical wounds, peripheral nerve damage, and microcirculation disorders, and achieves inhibition of platelet aggregation, promotion of nerve cell differentiation, improvement of The effect of microcirculation

Active Publication Date: 2013-09-04
JILIN YINGLIAN BIOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diabetic patients have impaired microcirculation and damaged peripheral nerves, making it difficult to heal surgical wounds and greatly increase the chance of co-infection, which poses a high risk of treatment.

Method used

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  • Pharmaceutical composition for treating diabetic feet caused by diabetes and acro-skin lesion and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating diabetic feet caused by diabetes and acro-skin lesion and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Element:

[0023] PGE1: 20mg, GM1: 2g;

[0024] HP-β-CD: 1.5g, petrolatum: 200g, polyacrylic acid: 100g, cetyl alcohol: 50g, triethanolamine: 3ml, Tween-80: 100g, glycerin: 50g, propylene glycol: 100g, benzoic acid: 0.5g, Absolute ethanol: 3ml, make up the balance with purified water.

[0025] Preparation method: Take PGE1 according to the prescription, add absolute ethanol to dissolve; take HP-β-CD and add purified water to dissolve, mix the two solutions, ultrasonically treat for 10 minutes, and freeze-dry. The obtained PGE1 inclusion compound is placed in a desiccator for later use; Polyacrylic acid, cetyl alcohol, heated to 75 ℃ to dissolve, and make an oil phase for later use; take PGE1 clathrate, monosialotetrahexosyl ganglioside (GM1), benzoic acid and add them to purified water, then add three Stir ethanolamine, Tween-80, glycerin, and propylene glycol evenly, and heat to 75°C to form a water phase; gradually add the water phase to the oil phase while stirring...

Embodiment 2

[0029] Element:

[0030] PGE1: 20mg, GM1: 10g;

[0031] HP-β-CD: 1.5g, petrolatum: 200g, polyacrylic acid: 50g, cetyl alcohol: 100g, triethanolamine: 5ml, Tween-80: 80g, glycerin: 50g, propylene glycol: 100g, benzoic acid: 0.5g, Absolute ethanol: 3ml, make up the balance with purified water.

[0032] Preparation method: Take PGE1 according to the prescription, add absolute ethanol to dissolve; take HP-β-CD and add purified water to dissolve, mix the two solutions, ultrasonically treat for 10 minutes, and freeze-dry. The obtained PGE1 inclusion compound is placed in a desiccator for later use; Polyacrylic acid, cetyl alcohol, heated to 75 ℃ to dissolve, and make an oil phase for later use; take PGE1 clathrate, monosialotetrahexosyl ganglioside (GM1), benzoic acid and add them to purified water, then add three Stir ethanolamine, Tween-80, glycerin, and propylene glycol evenly, and heat to 75°C to form a water phase; gradually add the water phase to the oil phase while stirring...

Embodiment 3

[0034] Element:

[0035] PGE1: 15mg, GM1: 20g;

[0036] HP-β-CD: 1.0g, petrolatum: 150g, polyacrylic acid: 50g, cetyl alcohol: 150g, triethanolamine: 5ml, Tween-80: 80g, glycerin: 75g, propylene glycol: 75g, benzoic acid: 0.8g, Absolute ethanol: 2ml, make up the balance with purified water.

[0037] Preparation method: Take PGE1 according to the prescription, add absolute ethanol to dissolve; take HP-β-CD and add purified water to dissolve, mix the two solutions, ultrasonically treat for 10 minutes, and freeze-dry. The obtained PGE1 inclusion compound is placed in a desiccator for later use; Polyacrylic acid, cetyl alcohol, heated to 75 ℃ to dissolve, and make an oil phase for later use; take PGE1 clathrate, monosialotetrahexosyl ganglioside (GM1), benzoic acid and add them to purified water, then add three Stir ethanolamine, Tween-80, glycerin, and propylene glycol evenly, and heat to 75°C to form a water phase; gradually add the water phase to the oil phase while stirring,...

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Abstract

The invention relates to pharmaceutical composition for treating diabetic feet caused by diabetes and acro-skin lesion and a preparation method of the pharmaceutical composition. The pharmaceutical composition is an ointment which is prepared by mixing prostaglandin E1 (PGE1) and monosialoteterahexosyl ganglioside (GM1) according to a proper proportion and adding an appropriate proportion of auxiliary materials. Experiments on animals show that the pharmaceutical composition has an ideal treatment effect on the diabetic feet caused by the diabetes and the acro-skin lesion, and is prepared into the ointment for external use and convenient to apply; an affected part is coated with the ointment directly; and the pharmaceutical composition can realize transdermal absorption, takes effect quickly, and is good in safety, clear in treatment effect, low in cost and good in adaptability of a patient.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating diabetic foot and extremity skin lesions caused by diabetes and a preparation method thereof. Background technique [0002] Diabetes-induced skin lesions, ie, complications of diabetes, are very common, with a variety of clinical manifestations. Almost all diabetic patients have skin involvement. These skin lesions are a reflection of metabolic disorders in diabetic patients, mainly including skin lesions caused by diabetic skin disease and diabetic neuropathy. [0003] Diabetic complications are a common chronic complication, diabetic peripheral neuropathy (DPN), eventually leading to diabetic foot or extremity lesions. The symptoms of diabetic peripheral neuropathy are symmetrical pain and paresthesia, and the lower extremity symptoms are more common than the upper extremity symptoms. Paraesthesias incl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P9/10A61P25/00A61P17/00A61K31/5575
Inventor 芦志刚王化宇
Owner JILIN YINGLIAN BIOPHARML
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