Prostaglandin compositions and method of treatment for male erectile dysfunction

An erectile dysfunction, prostaglandin technology, applied in drug combinations, sexual diseases, drug delivery, etc., can solve problems such as complication, unstable effort, etc.
CN1394140AInactive Publication Date: 2003-01-29NEXMED HLDG INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NEXMED HLDG INC
Publication Date
2003-01-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
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Description

field of invention

[0001] The present invention relates to compositions and methods suitable for treating erectile dysfunction, and more particularly to methods and pharmaceutical compositions suitable for intrascaphoid administration to the scaphoid fossa of a patient. Background of the invention

[0002] The term "impotence" is used to describe a male's inability to achieve and maintain an erection of the penis sufficient for satisfactory sexual intercourse. The term "erectile dysfunction" has been suggested as a more accurate term "denoting a male's inability to achieve penile erection as part of a multifaceted approach to overall male sexual function." Droller, M.J. et al. Impotence. Consensus Development Conference Statement, National Institutes of Health (1993).

[0003] The cause of erectile dysfunction may be psychological (psychogenic erectile dysfunction) or organic or both. Organ causes include physiological, neurological, vascular and hormonal pathologies or co...

Claims

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