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Testosterone transdermal absorbent patch

A testosterone and transdermal technology, which is applied in the direction of medical preparations of non-active ingredients, organic active ingredients, diseases, etc., can solve the problems of unsatisfactory transdermal absorption, unstable drug release, easy to fall off, etc., to achieve convenient Long-term administration, stable release process, and complete drug release effect

Active Publication Date: 2013-09-18
CHINA RESOURCES ZIZHU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The testosterone transdermal product prepared by the existing testosterone patch prescription and process has a high content of the main drug per unit area, and has the disadvantages of unsatisfactory transdermal absorption, unstable drug release, easy to fall off or difficult to remove during use, etc. To a large extent, it limits the clinical application of the therapeutic value of the drug

Method used

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  • Testosterone transdermal absorbent patch
  • Testosterone transdermal absorbent patch
  • Testosterone transdermal absorbent patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mix and dissolve the drug testosterone, penetration enhancer, propylene glycol, and copovidone in ethanol and ethyl acetate; then mix it with acrylic pressure-sensitive adhesive, stir and dissolve evenly, ultrasonicate for 20-30min, and let the drug stand until there are no bubbles. The liquid is evenly coated on the anti-adhesive layer, after being dried at a temperature of 30°C to 100°C in stages, the solvent is removed, and the backing layer is covered to prepare a testosterone transdermal absorption patch. Its specific prescription composition is as follows:

[0019]

[0020]

Embodiment 2

[0022] The testosterone transdermal absorption patch was prepared by the same method as in Example 1. Its prescription composition is as follows:

[0023]

Embodiment 3

[0025] The testosterone transdermal absorption patch was prepared by the same method as in Example 1. Its prescription composition is as follows:

[0026]

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PUM

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Abstract

The invention relates to a testosterone transdermal absorbent patch which consists of an anti-sticking layer, a drug-containing glue layer and a liner layer structure, and in particular relates to a compound type modifier formed by the combined action of a plurality of ingredients, so that the skin permeability and the medicine stability of the testosterone can be improved, and the prepared drug-containing glue layer is uniform and stable, more stable in a drug release process, and better in safety. The patch provided by the invention hardly falls off, and is easy to remove, and free from the phenomenon of glue residue during use process, thereby being good in clinic application prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms, and in particular relates to an improved testosterone transdermal absorption patch. Background technique [0002] Testosterone is a male hormone with the chemical name 17β-hydroxyandrost-4-en-3-one. It can be used clinically for testosterone replacement therapy for male hypogonadism. As a hormone supplement drug, long-term medication is generally required. [0003] The patch is a transdermal drug delivery system, and the drug can enter the systemic circulation through three stages: release, permeation and diffusion through the skin, and capillary absorption. Under a certain size and a suitable drug application area, the transdermal rate of the drug in the patch is a key factor to ensure its clinical efficacy. The patch needs to be adhered to the skin for drug administration. Generally, it needs to have good adhesion to ensure that it will not warp and fall off on the skin; i...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/10A61K47/34A61K47/14A61K47/18A61K31/568A61P15/08
Inventor 冉勇张艳郑焱刘杰贾君董艳敏冯晓庆张莉
Owner CHINA RESOURCES ZIZHU PHARMA
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